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Coping strategies and social support as mediators of consequences in child sexual abuse victims.
OBJECTIVE The main objective of this study was to evaluate the mediator role of coping strategies and social support on the adaptation of children following CSA. Empirical studies indicate that… Expand
Modeling T-cell acute lymphoblastic leukemia induced by the SCL and LMO1 oncogenes.
Deciphering molecular events required for full transformation of normal cells into cancer cells remains a challenge. In T-cell acute lymphoblastic leukemia (T-ALL), the genes encoding the TAL1/SCL… Expand
HES1 is a novel interactor of the Fanconi anemia core complex.
Fanconi anemia (FA) proteins are thought to play a role in chromosome stability and repair of DNA cross-links; however, these functions may not fully explain the developmental abnormalities and bone… Expand
SCL, LMO1 and Notch1 Reprogram Thymocytes into Self-Renewing Cells
The molecular determinants that render specific populations of normal cells susceptible to oncogenic reprogramming into self-renewing cancer stem cells are poorly understood. Here, we exploit T-cell… Expand
Requirement for Lyl1 in a model of Lmo2-driven early T-cell precursor ALL.
Lmo2 is an oncogenic transcription factor that is frequently overexpressed in T-cell acute lymphoblastic leukemia (T-ALL), including early T-cell precursor ALL (ETP-ALL) cases with poor prognosis.… Expand
ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling
Early T-cell precursor leukaemia (ETP-ALL) is a high-risk subtype of human leukaemia that is poorly understood at the molecular level. Here we report translocations targeting the zinc finger… Expand
The clonal evolution of leukemic stem cells in T-cell acute lymphoblastic leukemia
Purpose of reviewRecent genome sequencing studies have identified a broad spectrum of gene mutations in T-cell acute lymphoblastic leukemia (T-ALL). The purpose of this review is to outline the… Expand
Early T cell differentiation lessons from T-cell acute lymphoblastic leukemia.
- C. Tremblay, T. Hoang, T. Hoang
- Biology, Medicine
- Progress in molecular biology and translational…
T cells develop from bone marrow-derived self-renewing hematopoietic stem cells (HSC). Upon entering the thymus, these cells undergo progressive commitment and differentiation driven by the thymic… Expand
Loss-of-function mutations of Dynamin 2 promote T-ALL by enhancing IL-7 signalling
Mutations in the DYNAMIN2 (DNM2) gene are frequently detected in human acute T-cell lymphoblastic leukemia (T-ALL), although the mechanisms linking these mutations to disease pathogenesis remain… Expand
Conserved IKAROS-regulated genes associated with B-progenitor acute lymphoblastic leukemia outcome
- M. Witkowski, Yifang Hu, +15 authors R. Dickins
- Biology, Medicine
- The Journal of experimental medicine
- 6 March 2017
Genetic alterations disrupting the transcription factor IKZF1 (encoding IKAROS) are associated with poor outcome in B lineage acute lymphoblastic leukemia (B-ALL) and occur in >70% of the high-risk… Expand