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Akt interacts directly with Smad3 to regulate the sensitivity to TGF-β-induced apoptosis
Transforming growth factor β (TGF-β) induces both apoptosis and cell-cycle arrest in some cell lines, but only growth arrest in others. It is not clear how this differential response to TGF-β isExpand
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Establishment and characterization of an in vitro model system for human adenocarcinoma of the stomach.
Ten permanent clones derived from a single biopsy specimen of an untreated human adenocarcinoma of the stomach were established and characterized in vitro. Tissue culture growth properties, doublingExpand
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Establishment and characterization of a human carcinoid in nude mice and effect of various agents on tumor growth.
The authors have established a long-term tissue culture cell line (BON) derived from a metastatic human carcinoid tumor of the pancreas. The cells have been in continuous passage for 46 months.Expand
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Human Colorectal Cancers Express a Constitutively Active Cholecystokinin-B/Gastrin Receptor That Stimulates Cell Growth*
Although ectopic expression of the cholecystokinin B/gastrin receptor (CCK-BR) is widely reported in human colorectal cancers, its role in mediating the proliferative effects of gastrin1–17 (G-17) onExpand
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Characterization of a Human Pancreatic Carcinoid in Vitro: Morphology, Amine and Peptide Storage, and Secretion
The study of functioning human endocrine tumors has been hampered by a lack of suitable in vitro models. We have established the first permanent cell line of a human pancreatic carcinoid tumor (BON)Expand
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Current management of gastrointestinal carcinoid tumors
Gastrointestinal carcinoid tumors are rare neuroendocrine tumors arising from the embryologic primitive gut. Depending on the location in the gastrointestinal tract, these tumors may secrete aExpand
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Activator Protein-1 Transcription Factor Mediates Bombesin-stimulated Cyclooxygenase-2 Expression in Intestinal Epithelial Cells*
Colorectal carcinogenesis is a complex, multistep process involving genetic alterations and progressive changes in signaling pathways regulating intestinal epithelial cell proliferation,Expand
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Organ physiology of aging.
With improvements in medical care over the last several decades, individuals are living longer and, as a result, more surgical procedures will be performed in the geriatric patient. NormalExpand
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The Human Carcinoid Cell Line, BON
Carcinoid tumors are endocrine neoplasms derived from neuroectodermal cells (enterochromaffin cells) of the neural crest.!.? These tumors, primarily found in the gastrointestinal tract, are uncommonExpand
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