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The Tasmanian Devil Transcriptome Reveals Schwann Cell Origins of a Clonally Transmissible Cancer
Be-Deviled Cancer Recently, a deadly transmissible cancer has emerged in Tasmanian devils, the largest existing marsupial carnivore. This disease, devil facial tumor disease (DFTD), leads to theExpand
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Reversible epigenetic down-regulation of MHC molecules by devil facial tumour disease illustrates immune escape by a contagious cancer
Contagious cancers that pass between individuals as an infectious cell line are highly unusual pathogens. Devil facial tumor disease (DFTD) is one such contagious cancer that emerged 16 y ago and isExpand
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A second transmissible cancer in Tasmanian devils
Significance Transmissible cancers are somatic cell lineages that are spread between individuals via the transfer of living cancer cells. Only three transmissible cancers have been reported inExpand
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Novel application of a fish gill cell line assay to assess ichthyotoxicity of harmful marine microalgae
Fish-killingmicroalgae can cause substantial mortalities of cultured finfish, but their killing mechanisms are not completely understood. Since use of cell lines offers significant advantagesExpand
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Identification of dendritic cells, B cell and T cell subsets in Tasmanian devil lymphoid tissue; evidence for poor immune cell infiltration into devil facial tumors
The Tasmanian devil is under threat of extinction due to the transmissible devil facial tumor disease (DFTD). This fatal tumor is an allograft that does not induce an immune response, raisingExpand
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Regression of devil facial tumour disease following immunotherapy in immunised Tasmanian devils
Devil facial tumour disease (DFTD) is a transmissible cancer devastating the Tasmanian devil (Sarcophilus harrisii) population. The cancer cell is the ‘infectious’ agent transmitted as an allograftExpand
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A Murine Xenograft Model for a Transmissible Cancer in Tasmanian Devils
The number of Tasmanian devils in the wild is rapidly declining owing to a transmissible cancer, devil facial tumor disease (DFTD). Although progress has been made to understand the spread of thisExpand
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The newly-arisen Devil facial tumour disease 2 (DFT2) reveals a mechanism for the emergence of a contagious cancer
Devil Facial Tumour 2 (DFT2) is a recently discovered contagious cancer circulating in the Tasmanian devil (Sarcophilus harrisii), a species which already harbours a more widespread contagiousExpand
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Tumor-Specific Diagnostic Marker for Transmissible Facial Tumors of Tasmanian Devils
Devil facial tumor disease (DFTD) is a transmissible neoplasm that is threatening the survival of the Tasmanian devil. Genetic analyses have indicated that the disease is a peripheral nerve sheathExpand
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Evidence for induction of humoral and cytotoxic immune responses against devil facial tumor disease cells in Tasmanian devils (Sarcophilus harrisii) immunized with killed cell preparations.
Tasmanian devils (Sarcophilus harrisii) risk extinction from a contagious cancer, devil facial tumour disease (DFTD) in which the infectious agent is the tumor cell itself. Because devils are unableExpand
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