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The anterolateral ligament of the knee: a radiologic and histotopographic study
TLDR
The antero-lateral ligament shows the typical structure of a fibrous ligament from the anatomo-radiological point of view and is almost constantly depicted by routine 1.5-T MR scan. Expand
Orexins stimulate corticosterone secretion of rat adrenocortical cells, through the activation of the adenylate cyclase-dependent signaling cascade
TLDR
Findings suggest that orexins exert a selective and direct glucocorticoid secretagogue action on the rat adrenals, acting through a receptor-mediated activation of the adenylate cyclase/PKA-dependent signaling pathway. Expand
Orexins stimulate glucocorticoid secretion from cultured rat and human adrenocortical cells, exclusively acting via the OX1 receptor
TLDR
It is concluded that orexins stimulate glucocorticoid secretion from rat and human adrenocortical cells, exclusively acting through OX1-Rs coupled to the adenylate cyclase/PKA-dependent signaling cascade. Expand
Exendin-4, a GLP-1 receptor agonist, stimulates pituitary-adrenocortical axis in the rat: Investigations into the mechanism(s) underlying Ex4 effect.
Exendin-4 (Ex4) is a potent and long-lasting agonist of glucagon-like peptide-1 (GLP-1), which has been previously found to stimulate pituitary-adrenal axis in the rat. Aim of the present study wasExpand
Ghrelin, an endogenous ligand for the growth hormone-secretagogue receptor, is expressed in the human adrenal cortex.
TLDR
The present coupled RT-PCR, RIA and autoradiographic findings could suggest the involvement of ghrelin in the autocrine-paracrine regulation of human adrenal growth. Expand
Urotensin-II-stimulated expression of pro-angiogenic factors in human vascular endothelial cells
TLDR
The expression of three pro-angiogenic factors, namely VEGF, endothelin-1, and adrenomedullin, was studied in human umbilical vein endothelial cells (HUVEC) for longer times of U-II stimulation and indicated that in HUVEC, exposed for at least 24h to U- II, the expression of the three angiogenic molecules was significantly increased at both mRNA and protein level. Expand
Evidence that endogenous vasoactive intestinal peptide (VIP) is involved in the regulation of rat pituitary-adrenocortical function: in vivo studies with a VIP antagonist
TLDR
Exogenous VIP does not regulate HPA-axis function under basal conditions, but it plays a pivotal role in the mechanisms involved in the activation of HPA axis induced by cold exposure, and endogenous VIP exerts a tonic stimulatory action on ALDO secretion, probably by acting directly on the adrenal zona glomerulosa. Expand
Effects of neuromedin U (NMU)-8 on the rat hypothalamo-pituitary-adrenal axis. Evidence of a direct effect of NMU-8 on the adrenal gland
TLDR
It seems reasonable to suggest that NMU-8 exerts a biphasic effect on the function of the peripheral branch of the hypothalamo-pituitary-adrenal axis in rats: NMU -8 at low doses directly stimulates the function and growth of the adrenal cortex, while at high doses exerting a direct inhibitory action. Expand
Endothelins stimulate aldosterone secretion from dispersed rat adrenal zona glomerulosa cells, acting through ETB receptors coupled with the phospholipase C-dependent signaling pathway
TLDR
Findings suggest that endothelins stimulate aldosterone secretion from rat ZG cells through the activation of PLC-coupled ETB receptors, and PLC stimulation leads to theactivation of PKC and to the rise in [Ca2+]i with the ensuing activation of calmodulin, which is exclusively dependent on the stimulation of IP(3)-dependent Ca2+ release from intracellular stores. Expand
Endothelin-1 stimulates aldosterone synthesis in Conn's adenomas via both A and B receptors coupled with the protein kinase C- and cyclooxygenase-dependent signaling pathways.
TLDR
It is found that Ang-II and ET-1 equipotently stimulate both early and late steps of aldosterone synthesis in Conn's adenoma cells, indicating that the mechanisms and factors leading to enhanced ald testosterone secretion and ultimately to neoplastic transformation of the adrenal cortex are poorly defined. Expand
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