C. Toh

Publications192
h-index37
Citations7,175
Highly Influential Citations257
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Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation.
TLDR
This poster presents a poster presented at the European Hemophilia and Vascular Biology Conference in Brussels, Belgium, which aims to present a probabilistic picture of the immune system’s response to blood clotting disorders.
Circulating histones are mediators of trauma-associated lung injury.
  • S. Abrams, N. Zhang, C. Toh
  • Medicine, Biology
    American journal of respiratory and critical care…
  • 15 January 2013
TLDR
A new mechanism for acute lung injury after severe trauma is elucidated and it is proposed that circulating histones are viable therapeutic targets for improving survival outcomes in patients.
Disseminated intravascular coagulation in obstetric disorders and its acute haematological management.
Loss of endothelial protein C receptors links coagulation and inflammation to parasite sequestration in cerebral malaria in African children.
TLDR
It is demonstrated that loss of EPCR and TM at sites of IE cytoadherence is detectible in nonfatal CM and these data implicate disruption of the endothelial protective properties at vulnerable sites and particularly in the brain, linking coagulation and inflammation with IE sequestration.
The scoring system of the Scientific and Standardisation Committee on Disseminated Intravascular Coagulation of the International Society on Thrombosis and Haemostasis: a 5‐year overview 1
In 2001, the International Society on Thrombosis and Haemostasis (ISTH) Sub-Committee of the Scientific and Standardisation Committee (SSC) on Disseminated Intravascular Coagulation (DIC) proposed…
Circulating Histones Are Major Mediators of Cardiac Injury in Patients With Sepsis*
TLDR
In vivo studies on septic mice confirmed the cause-effect relationship between circulating histones and the development of cardiac injury, arrhythmias, and left ventricular dysfunction.
Genetic and environmental factors determining clinical outcomes and cost of warfarin therapy: a prospective study
TLDR
Accurate prediction of warfarin dose requirement needs to take into account multiple genetic and environmental factors, the contributions of which vary in the induction and maintenance phases of treatment.
Autocrine VEGF mediates the antiapoptotic effect of CD154 on CLL cells
TLDR
It is concluded that CLL-cell cytoprotection in the presence of CD154 requires combined signalling by both CD40 and VEGFR, and autocrine VEGF is identified as an important mediator of the antiapoptotic effect of CD40 ligation.
Novel and diagnostically applicable information from optical waveform analysis of blood coagulation in disseminated intravascular coagulation
Transmittance waveform is the term applied to the optical profile generated from the process of clot formation on standard coagulation tests run on the MDA‐180, a new‐generation automated coagulation…
Guidance for diagnosis and treatment of disseminated intravascular coagulation from harmonization of the recommendations from three guidelines
Three guidelines have recently been published for the diagnosis and treatment of disseminated intravascular coagulation (DIC) in adults. This communication seeks to harmonize the recommendations in…
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