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Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation.
1. Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 2. Department of Haematology, Royal Liverpool University Hospital, Liverpool, UK 3. University ofExpand
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Circulating histones are mediators of trauma-associated lung injury.
RATIONALE Acute lung injury is a common complication after severe trauma, which predisposes patients to multiple organ failure. This syndrome largely accounts for the late mortality that arises andExpand
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Guidelines for the diagnosis and management of disseminated intravascular coagulation
The diagnosis of disseminated intravascular coagulation (DIC) should encompass both clinical and laboratory information. The International Society for Thrombosis and Haemostasis (ISTH) DIC scoringExpand
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Disseminated intravascular coagulation in obstetric disorders and its acute haematological management.
As activation of the coagulation pathway is a physiological response to injury, the development of disseminated intravascular coagulation (DIC) is a warning signal to the clinician that the primaryExpand
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Guidance for diagnosis and treatment of disseminated intravascular coagulation from harmonization of the recommendations from three guidelines
Three guidelines have recently been published for the diagnosis and treatment of disseminated intravascular coagulation (DIC) in adults. This communication seeks to harmonize the recommendations inExpand
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Loss of endothelial protein C receptors links coagulation and inflammation to parasite sequestration in cerebral malaria in African children.
Cerebral malaria (CM) is a major cause of mortality in African children and the mechanisms underlying its development, namely how malaria-infected erythrocytes (IEs) cause disease and why the brainExpand
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Genetic and environmental factors determining clinical outcomes and cost of warfarin therapy: a prospective study
Background In this prospective cohort study, we have undertaken a comprehensive evaluation of clinical parameters along with variation in 29 genes (including CYP2C9 and VKORC1) to identify factorsExpand
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Circulating Histones Are Major Mediators of Cardiac Injury in Patients With Sepsis*
Objective:To investigate the impact of circulating histones on cardiac injury and dysfunction in a murine model and patients with sepsis. Design:Prospective, observational clinical study with in vivoExpand
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Autocrine VEGF mediates the antiapoptotic effect of CD154 on CLL cells
CD154 is an important regulator of chronic lymphocytic leukaemia (CLL)-cell survival. In CLL, high serum levels of VEGF are a feature of advanced disease, and we and others have previously shown thatExpand
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Novel and diagnostically applicable information from optical waveform analysis of blood coagulation in disseminated intravascular coagulation
Transmittance waveform is the term applied to the optical profile generated from the process of clot formation on standard coagulation tests run on the MDA‐180, a new‐generation automated coagulationExpand
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