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ω-3 oil intake during weight loss in obese women results in remodelling of plasma triglyceride and fatty acids
Previous studies have shown that a combination of weight loss and fish oil supplementation reduce cardiovascular disease and diabetes risks by increasing adiponectin and reducing triacylglyceride… Expand
A Molecular Switch and Proton Wire Synchronize the Active Sites in Thiamine Enzymes
Thiamine diphosphate (ThDP) is used as a cofactor in many key metabolic enzymes. We present evidence that the ThDPs in the two active sites of the E1 (EC 220.127.116.11) component of the pyruvate… Expand
Polynucleotide Phosphorylase Activity May Be Modulated by Metabolites in Escherichia coli*♦
- S. Nurmohamed, H. A. Vincent, +6 authors B. Luisi
- Biology, Medicine
- The Journal of Biological Chemistry
- 14 February 2011
RNA turnover is an essential element of cellular homeostasis and response to environmental change. Whether the ribonucleases that mediate RNA turnover can respond to cellular metabolic status is an… Expand
A matter of fat: an introduction to lipidomic profiling methods.
- L. D. Roberts, G. McCombie, C. Titman, J. Griffin
- Chemistry, Medicine
- Journal of chromatography. B, Analytical…
- 15 August 2008
In recent years, lipidomics or lipid profiling, an extension of metabolomics where the lipid complement of a cell, tissue or organism is measured, has been the recipient of increasing attention as a… Expand
Snapshots of Catalysis in the E1 Subunit of the Pyruvate Dehydrogenase Multienzyme Complex
Summary The pyruvate dehydrogenase multienzyme assembly (PDH) generates acetyl coenzyme A and reducing equivalents from pyruvate in a multiple-step process that is a nexus of central metabolism. We… Expand
Applications of metabolomics to understanding obesity in mouse and man.
The functional genomic approach of metabolomics consists of the application of a global analytical tool to profile metabolism in a cell, tissue or organism. The most popular analytical tools include… Expand
A metabolomic and multivariate statistical process to assess the effects of genotoxins in Saccharomyces cerevisiae.
- C. Titman, J. Downs, S. Oliver, P. Carmichael, A. Scott, J. Griffin
- Biology, Medicine
- Molecular bioSystems
- 12 November 2009
There is an increased need to develop robust cellular model systems which could replace or reduce the need for animals in toxicological testing. Current in vitro strategies for genotoxicity testing… Expand
A Molecular Switch and Proton-Wire Synchronize the Active Sites in Thiamine-Dependent Enzymes
Multi-residue determination of anticoagulant rodenticides in vertebrate wildlife and domestic animals using Ultra (High) Performance Liquid Chromatography Tandem Mass Spectrometry