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NMDA receptor function is regulated by the inhibitory scaffolding protein, RACK1
Phosphorylation regulates the function of ligand-gated ion channels such as the N-methyl d-aspartate (NMDA) receptor. Here we report a mechanism for modulation of the phosphorylation state andExpand
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Metabolism and pharmacokinetics of bisphenol A (BPA) and the embryo-fetal distribution of BPA and BPA-monoglucuronide in CD Sprague-Dawley rats at three gestational stages.
The pharmacokinetics of bisphenol A (BPA), including the quantification of the major BPA metabolite BPA-monoglucuronide conjugate (BPA-glucuronide) was studied in Sprague-Dawley rats at differentExpand
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Mind Bomb-2 Is an E3 Ligase That Ubiquitinates the N-Methyl-d-aspartate Receptor NR2B Subunit in a Phosphorylation-dependent Manner*
The N-methyl-d-aspartate receptor (NMDAR) plays a critical role in synaptic plasticity. Post-translational modifications of NMDARs, such as phosphorylation, alter both the activity and traffickingExpand
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Spatial and Temporal Regulation of RACK1 Function and N-methyl-D-aspartate Receptor Activity through WD40 Motif-mediated Dimerization*
Efficient signaling requires accurate spatial and temporal compartmentalization of proteins. RACK1 is a scaffolding protein that fulfils this role through interaction of binding partners with one ofExpand
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Pediatric malignant germ cell tumors show characteristic transcriptome profiles.
Malignant germ cell tumors (GCT) of childhood are rare and heterogeneous neoplasms thought to arise from primordial germ cells. They vary substantially in their natural history and show importantExpand
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A regional audit of perinatal and infant autopsies in Northern Ireland
Objective To investigate the rate and quality of perinatal/infant autopsies and their contribution to the final diagnosis.
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Malignant germ cell tumors display common microRNA profiles resulting in global changes in expression of messenger RNA targets.
Despite their extensive clinical and pathologic heterogeneity, all malignant germ cell tumors (GCT) are thought to originate from primordial germ cells. However, no common biological abnormalitiesExpand
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Age and dose dependency of the pharmacokinetics and metabolism of bisphenol A in neonatal sprague-dawley rats following oral administration.
Previous studies demonstrated the rapid clearance of bisphenol A (BPA) from blood following oral administration to adult rats with the principal metabolite being BPA-monoglucuronideExpand
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Potential mechanisms of tumorigenic action of diethanolamine in mice.
Diethanolamine (DEA), a secondary amine found in a number of consumer products, reportedly induces liver tumors in mice. In an attempt to define the tumorigenic mechanism of DEA,Expand
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Quasi–static deformation of particulate media
  • C. Thornton, S. Antony
  • Materials Science, Biology
  • Philosophical Transactions of the Royal Society…
  • 15 November 1998
Quasi–static shear deformation of granular media is examined by performing numerical simulations on polydisperse systems of elastic spheres in a periodic cell. Results of axisymmetric compressionExpand
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