C. Thompson

Publications673
h-index200
Citations177,520
Highly Influential Citations7,066
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Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
TLDR
It is proposed that the metabolism of cancer cells, and indeed all proliferating cells, is adapted to facilitate the uptake and incorporation of nutrients into the biomass needed to produce a new cell.
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An inhibitor of Bcl-2 family proteins induces regression of solid tumours
TLDR
Mechanistic studies reveal that ABT-737 does not directly initiate the apoptotic process, but enhances the effects of death signals, displaying synergistic cytotoxicity with chemotherapeutics and radiation.
View on Nature
Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death
Multiple death signals influence mitochondria during apoptosis, yet the critical initiating event for mitochondrial dysfunction in vivo has been unclear. tBID, the caspase-activated form of a…
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Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
TLDR
It is shown that cancer-associated IDH1 mutations result in a new ability of the enzyme to catalyse the NADPH-dependent reduction of α-ketoglutarate to R(-)-2-hydroxyglutarate (2HG), and that the excess 2HG which accumulates in vivo contributes to the formation and malignant progression of gliomas.
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Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation.
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The biology of cancer: metabolic reprogramming fuels cell growth and proliferation.
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bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death
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Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes
TLDR
A set of guidelines for the selection and interpretation of the methods that can be used by investigators who are attempting to examine macroautophagy and related processes, as well as by reviewers who need to provide realistic and reasonable critiques of papers that investigate these processes are presented.
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Bad, a heterodimeric partner for Bcl-xL and Bcl-2, displaces bax and promotes cell death
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Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction
TLDR
It is reported that the transcriptional regulatory properties of the oncogene Myc coordinate the expression of genes necessary for cells to engage in glutamine catabolism that exceeds the cellular requirement for protein and nucleotide biosynthesis, resulting in the reprogramming of mitochondrial metabolism to depend on glutaminolysis to sustain cellular viability and TCA cycle anapleurosis.
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