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Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
- M. V. Vander Heiden, L. Cantley, C. Thompson
- BiologyScience
- 22 May 2009
TLDR
An inhibitor of Bcl-2 family proteins induces regression of solid tumours
- T. Oltersdorf, S. Elmore, S. Rosenberg
- BiologyNature
- 2 June 2005
TLDR
Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death
- M. Wei, W. Zong, S. Korsmeyer
- BiologyScience
- 27 April 2001
Multiple death signals influence mitochondria during apoptosis, yet the critical initiating event for mitochondrial dysfunction in vivo has been unclear. tBID, the caspase-activated form of a…
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
TLDR
Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation.
- M. Figueroa, O. Abdel-Wahab, A. Melnick
- BiologyCancer cell
- 14 December 2010
The biology of cancer: metabolic reprogramming fuels cell growth and proliferation.
- R. Deberardinis, J. Lum, G. Hatzivassiliou, C. Thompson
- BiologyCell metabolism
- 2008
bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death
- L. Boise, M. González-García, C. Thompson
- BiologyCell
- 27 August 1993
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes
- D. Klionsky, H. Abeliovich, R. Deter
- BiologyAutophagy
- 16 February 2008
TLDR
Bad, a heterodimeric partner for Bcl-xL and Bcl-2, displaces bax and promotes cell death
- E. Yang, J. Zha, J. Jockel, L. Boise, C. Thompson, S. Korsmeyer
- BiologyCell
- 27 January 1995
Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction
- David R. Wise, R. Deberardinis, C. Thompson
- BiologyProceedings of the National Academy of Sciences
- 2 December 2008
TLDR
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