XRCC1 polymorphisms: effects on aflatoxin B1-DNA adducts and glycophorin A variant frequency.
The results suggest that the Arg399Gln amino acid change may alter the phenotype of the XRCC1 protein, resulting in deficient DNA repair.
Hemoglobin adducts from acrylonitrile and ethylene oxide in cigarette smokers: effects of glutathione S-transferase T1-null and M1-null genotypes.
- T. Fennell, J. MacNeela, R. W. Morris, M. Watson, C. Thompson, D. Bell
- BiologyCancer Epidemiology, Biomarkers and Prevention
- 1 July 2000
The lack of a functional GSTT1 is estimated to increase the internal dose of EO derived from cigarette smoke by 50-70% and CEVal and HEVal levels increased with increased cigarette smoking dose (both self-reported and cotinine-based).
Genetic monitoring of human polymorphic cancer susceptibility genes by polymerase chain reaction: application to glutathione transferase mu.
This study has compared the GST1 genotype to lymphocyte GT mu activity measured on trans-stilbene oxide (TSO) in the lymphocytes of 45 individuals and found individuals with the highest GT-TSO activity were found to be homozygous for GST1.
CYP1A1 mRNA levels as a human exposure biomarker: use of quantitative polymerase chain reaction to measure CYP1A1 expression in human peripheral blood lymphocytes.
A quantitative competitive RT-PCR method was developed that determined copy numbers of CYP1A1 mRNA in resting as well as mitogen-stimulated human blood lymphocytes and mRNA levels correlated well with ethoxyresorufin-O-deethylase (EROD) activity.
Sex differences in estrogen binding by cytosolic and nuclear components of rat liver.
Correlation of hepatic estrogen receptor concentrations and estrogen-mediated elevation of very low density lipoproteins.
After 2 weeks of administration of 17β-estradiol (E2; ∼20–30 Mg E2/kg BW-day) to adult ovariectomized female rats, concentrations of circulating triglycerides were increased 3- to 4-fold with no…
Impact of age and environment on somatic mutation at the hprt gene of T lymphocytes in humans.
Spectrum of somatic mutation at the hypoxanthine phosphoribosyltransferase (hprt) gene of healthy people.
This study provides an excellent base for comparison of mutation spectra in other human populations and identifies three hotspots for mutations at basepairs 197, 508 and 617 in the hprt gene coding region.
Effect of gonadectomy on the ontogeny of estrogen-binding components in rat liver cytosol.
It is suggested that sexual differentiation of high capacity estrogen-binding sites may be programmed at birth by testicular androgens.
Sex differences in hepatic oestrogen-binding proteins.
A multiplicity of oestrogen-binding proteins in liver cytosol is demonstrated and the possibility that the presence of some of these proteins may be imprinted at birth through the hypothalamic-pituitary axis, by a mechanism requiring neonatal androgen exposure is raised.