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Genetic correction of a LRRK2 mutation in human iPSCs links parkinsonian neurodegeneration to ERK-dependent changes in gene expression.
It is shown that multiple PD-associated phenotypes were ameliorated by inhibition of ERK, providing mechanistic insight into the pathogenesis induced by mutant LRRK2 and pointers for the development of potential new therapeutics. Expand
Derivation and Expansion Using Only Small Molecules of Human Neural Progenitors for Neurodegenerative Disease Modeling
Phenotypic drug discovery requires billions of cells for high-throughput screening (HTS) campaigns. Because up to several million different small molecules will be tested in a single HTS campaign,Expand
A readily retrievable pool of synaptic vesicles
This study monitored the temporal dynamics of a presorted and preassembled pool of synaptic vesicle proteins on the presynaptic membrane in rat hippocampal neurons using a new type of probe and demonstrated the preferential recruitment of a surface pool of neurotransmitter proteins upon stimulated endocytosis. Expand
Amyloid Precursor Protein Is Trafficked and Secreted via Synaptic Vesicles
It is demonstrated that a small but relevant number of synaptic vesicles contain APP, which can be released during neuronal activity, and most likely represent the major exocytic pathway of APP. Expand
Regulation of ICAM-1 in Cells of the Monocyte/Macrophage System in Microgravity
Cells of the immune system are highly sensitive to altered gravity, and the monocyte as well as the macrophage function is proven to be impaired under microgravity conditions. In our study, weExpand
Astrobiology and habitability studies in preparation for future Mars missions: trends from investigating minerals, organics and biota
Abstract Several robotic exploration missions will travel to Mars during this decade to investigate habitability and the possible presence of life. Field research at Mars analogue sites such asExpand
PCR-based analysis of microbial communities during the EuroGeoMars campaign at Mars Desert Research Station, Utah
For the first time, it is demonstrated that it is possible to perform direct on-site DNA analysis by PCR at MDRS, a simulated planetary habitat in an extreme environment that serves as a model for preparation and optimization of techniques to be used for future Mars exploration. Expand
Rapid alterations of cell cycle control proteins in human T lymphocytes in microgravity
It is suppose that cell cycle progression in human T lymphocytes requires Earth gravity and that the disturbed expression of cell cycle regulatory proteins could contribute to the breakdown of the human immune system in space. Expand
Cytoskeletal stability and metabolic alterations in primary human macrophages in long-term microgravity
The CELLBOX-PRIME experiment investigated for the first time microgravity-associated long-term alterations in primary human macrophages, one of the most important effector cells of the immune system, and assumes that the surprisingly small and non-significant cytoskeletal alterations represent a stable “steady state” after adaptive processes are initiated in the new microgravity environment. Expand
T cell regulation in microgravity – The current knowledge from in vitro experiments conducted in space, parabolic flights and ground-based facilities
This review gives an overview of the current knowledge of T cell regulation under altered gravity conditions obtained by in vitro studies with special emphasis on the cell culture conditions used and proposes that future in vitro experiments should follow rigorous standardized cellculture conditions. Expand