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Preferential incorporation of adult-generated granule cells into spatial memory networks in the dentate gyrus
Throughout adulthood, new neurons are continuously added to the dentate gyrus, a hippocampal subregion that is important in spatial learning. Whether these adult-generated granule cells becomeExpand
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Involvement of the Anterior Cingulate Cortex in the Expression of Remote Spatial Memory
Although the hippocampus plays a crucial role in the formation of spatial memories, as these memories mature they may become additionally (or even exclusively) dependent on extrahippocampalExpand
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Stimulation of Entorhinal Cortex Promotes Adult Neurogenesis and Facilitates Spatial Memory
Deep brain stimulation (DBS) is an established therapeutic modality for the treatment of movement disorders and an emerging therapeutic approach for the treatment of disorders of mood and thought.Expand
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Reelin Regulates Postnatal Neurogenesis and Enhances Spine Hypertrophy and Long-Term Potentiation
Reelin, an extracellular protein essential for neural migration and lamination, is also expressed in the adult brain. To unravel the function of this protein in the adult forebrain, we generatedExpand
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Functional convergence of developmentally and adult‐generated granule cells in dentate gyrus circuits supporting hippocampus‐dependent memory
In the hippocampus, the production of dentate granule cells (DGCs) persists into adulthood. As adult‐generated neurons are thought to contribute to hippocampal memory processing, promoting adultExpand
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The precision of remote context memories does not require the hippocampus
Although the clarity of many memories fades with time, some memories may maintain their original precision. Here we used a context discrimination procedure to evaluate whether the hippocampus isExpand
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Identification of a Functional Connectome for Long-Term Fear Memory in Mice
TLDR
We used a global mapping approach to identify networks of brain regions activated following recall of long-term fear memories in mice. Expand
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Imaging activation of adult-generated granule cells in spatial memory
New neurons are continuously generated in the subgranular zone of the hippocampus throughout adulthood, and there is increasing interest as to whether these new neurons become functionally integratedExpand
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Reelin delays amyloid-beta fibril formation and rescues cognitive deficits in a model of Alzheimer's disease.
Reelin is an extracellular matrix protein that is crucial for neural development and adult brain plasticity. While the Reelin signalling cascade has been reported to be associated with Alzheimer'sExpand
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Dopamine and serotonin signaling during two sensitive developmental periods differentially impact adult aggressive and affective behaviors in mice
Pharmacologic blockade of monoamine oxidase A (MAOA) or serotonin transporter (5-HTT) has antidepressant and anxiolytic efficacy in adulthood. Yet, genetically conferred MAOA or 5-HTT hypoactivity isExpand
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