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Natural and synthetic non-peptide antigens recognized by human gamma delta T cells.
T lymphocytes express either alpha beta or gamma delta T-cell receptor heterodimers. Most alpha beta T cells recognize antigenic peptides bound to major histocompatibility complex molecules but theExpand
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Natural and synthetic non-peptide antigens recognized by human γδ T cells
T LYMPHOCYTES express either αβ or γδ T-cell receptor heterodimers1,2. Most αβ T cells recognize antigenic peptides bound to major histocompatibility complex molecules but the antigen recognition andExpand
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Nonpeptide antigens, presentation mechanisms, and immunological memory of human Vγ2Vδ2 T cells: discriminating friend from foe through the recognition of prenyl pyrophosphate antigens
Summary:  Human Vγ2Vδ2 T cells play important roles in mediating immunity against microbial pathogens and have potent anti‐tumor activity. Vγ2Vδ2 T cells recognize the pyrophosphorylated isoprenoidExpand
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CDlb restricts the response of human CD4−8−T lymphocytes to a microbial antigen
MOLECULES encoded by the human GDI locus on chromosome 1 (ref. 33) are recognized by selected CD4−8− T-cell clones expressing either αβ or γδ T-cell antigen receptors1,2. The known structuralExpand
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Recognition of a lipid antigen by CD1-restricted alpha beta+ T cells.
Major histocompatibility complex (MHC) class I and class II molecules bind immunogenic peptides and present them to lymphocytes bearing the alpha beta T-cell antigen receptor (TCR). An analogousExpand
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Direct presentation of nonpeptide prenyl pyrophosphate antigens to human gamma delta T cells.
Human V gamma 2V delta 2+ T cells recognize mycobacterial nonpeptide antigens, such as isopentenyl pyrophosphate, and their synthetic analogs, such as monoethyl phosphate, through a TCR-dependentExpand
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The Syk family of protein tyrosine kinases in T‐cell activation and development
Summary: The processes of T‐cell development and activation employ similar immature and mature receptors as well as similar signal transduction pathways to achieve different outcomes. Many signalingExpand
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Cytokine Requirements for the Differentiation and Expansion of IL-17A– and IL-22–Producing Human Vγ2Vδ2 T Cells
Human γδ T cells expressing the Vγ2Vδ2 TCR play important roles in immune responses to microbial pathogens by monitoring prenyl pyrophosphate isoprenoid metabolites. Most adult Vγ2Vδ2 cells areExpand
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V gamma 2V delta 2 TCR-dependent recognition of non-peptide antigens and Daudi cells analyzed by TCR gene transfer.
The predominant subpopulation of gamma delta T cells in human peripheral blood expresses TCR V region genes V gamma 2 paired with V delta 2. Previous studies have shown that these V gamma 2V delta 2+Expand
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Nonpeptide ligands for human gamma delta T cells.
gamma delta T cells respond to a variety of microbial pathogens and transformed cells. Their limited receptor repertoire and activation by mycobacterial antigens resistant to proteases suggest thatExpand
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