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Biochemical characterization and molecular dynamic simulation of β-sitosterol as a tubulin-binding anticancer agent.
TLDR
The data suggest that β-SITO is a potent anticancer compound that interferes with microtubule assembly dynamics by binding to a novel site on tubulin.
Periodontal findings in patients with oral submucous fibrosis and comet assay of affected gingival epithelial cells.
TLDR
OSF showed significant changes in affected gingiva, and the presence of comet cells in all the patients with OSF is a significant indicator of possible pathognomonic developments.
Molecular insight into γ–γ tubulin lateral interactions within the γ-tubulin ring complex (γ-TuRC)
TLDR
This study uses molecular modelling and molecular dynamics simulations and computational MM-PBSA/MM-GBSA methods to determine the extent of the lateral atomic interaction between two adjacent γ-tubulins within the γTuRC, and identifies hotspot amino acids responsible for key γ–γ interactions.
ORIGINAL ARTICLE The Immunohistochemical Evaluation Of The Expression Of Bcl-2 In Different Histological Grades Of Squamous Cell Carcinoma
TLDR
In OSCCs, the number of cells expressing bcl-2 increased from well differentiated to poorly differentiated, showing an inverse relationship with the degree of differentiation.
Comparision of Immunohistochemical Expression of CD10 in Odontogenic Cysts.
TLDR
CD10 expression was more in OKC compared to radicular and dentigerous cysts, and more number of cases showing sub-epithelial stromal CD10 expression were found inOKC among the cysts.
A Non-Invasive Technique which Demonstrates the Iron in the Buccal Mucosa of Sickle Cell Anaemia and Thalassaemia Patients who Undergo Repeated Blood Transfusions.
TLDR
It was observed that as the serum ferritin levels increased, the iron overload in the oral mucosal cells of the thalassaemia patients also increased, which was not statistically significant, whereas it was statistically significant in case of the sickle cell anemia patients.
Rational design of biaryl pharmacophore inserted noscapine derivatives as potent tubulin binding anticancer agents
TLDR
The newly designed noscapinoid, 5e is an orally bioavailable, safe and effective anticancer agent with a potential for the treatment of cancer and might be a candidate for clinical evaluation.
Elucidation of the anticancer potential and tubulin isotype-specific interactions of β-sitosterol
TLDR
The data show the tubulin-targeted anticancer potential of β-SITO, and its potential clinical utility against βII and βIII isotype-overexpressing neoplasms.
Molecular dynamics simulation reveals the possible druggable hot-spots of USP7
TLDR
A dynamically stable allosteric binding site near catalytic center of the inactive state of USP7 (site partially absent in active state), along with two newly identified sites have been revealed, which opens the avenue for rational structure-guided inhibitor designing in USP6 specific-manner.
Insights into structural dynamics of allosteric binding sites in HCV RNA-dependent RNA polymerase
TLDR
The structural insights are explored to understand the correlation between the dynamics of protein’s subdomains and function at the molecular level, useful for genotype-specific rational designing of NNIs.
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