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Genome sequences of the human body louse and its primary endosymbiont provide insights into the permanent parasitic lifestyle
- E. Kirkness, B. Haas, B. Pittendrigh
- BiologyProceedings of the National Academy of Sciences
- 21 June 2010
The genome sequences of the body louse and its primary bacterial endosymbiont Candidatus Riesia pediculicola are presented, providing a reference for studies of holometabolous insects.
Study designs for evaluating different efficacy and effectiveness aspects of vaccines.
A framework of study designs is presented that relates the scientific question of interest to the choice of comparison groups, the unit of observation, the level of information available for analysis, and the parameter of effect.
Design and Analysis of Vaccine Studies
and Examples.- Overview of Vaccine Effects and Study Designs.- Immunology and Early Phase Trials.- Binomial and Stochastic Transmission Models.- and Deterministic Models.- Evaluating Protective…
SARS-CoV-2 antibody prevalence in Brazil: results from two successive nationwide serological household surveys
Highly evolvable malaria vectors: The genomes of 16 Anopheles mosquitoes
Anopheline mosquitoes exhibit a molecular evolutionary profile very distinct from Drosophila, and their genomes harbor strong evidence of functional variation in traits that determine vectorial capacity, which suggests an underlying genetic/genomic plasticity that results in variation of key traits determiningvectorial capacity within the genus.
Causal Inference in Infectious Diseases
The model proposed by Rubin for causal inference based on the potential outcomes if individuals received each of the treatments under study for infectious disease is reviewed, and the role of differential exposure to infection in direct and indirect effects is contrasted.
Gestational weight gain and prepregnancy weight influence postpartum weight retention in a cohort of brazilian women.
- G. Kac, M. H. Benício, G. Velásquez-Melendez, J. Valente, C. Struchiner
- MedicineThe Journal of nutrition
- 1 March 2004
G gestational weight gain was one of the most important predictors for post partum weight retention and must be monitored systematically with the aim of preventing postpartum obesity and the diseases that follow.
Direct and indirect effects in vaccine efficacy and effectiveness.
- M. Halloran, M. Haber, I. Longini, C. Struchiner
- PsychologyAmerican journal of epidemiology
- 15 February 1991
Two classes of parameters are distinguished along lines differing from the conventional distinction between efficacy and effectiveness: Efficacy parameters attempt to control for exposure to infection and represent direct effects on individuals and indirect effects in the population.
Global pharmacogenomics: Impact of population diversity on the distribution of polymorphisms in the CYP2C cluster among Brazilians
The intrinsic heterogeneity of the Brazilian population must be acknowledged in the design and interpretation of pharmacogenomic studies of the CYP2C cluster in order to avoid spurious conclusions based on improper matching of study cohorts.
Population-based surveys of antibodies against SARS-CoV-2 in Southern Brazil
Three separate rounds of serological surveys in the state of Rio Grande do Sul in Brazil from mid-April to mid-May 2020 show an increase in antibodies specific for SARS-CoV-2 over time, with a significant upward trend over the course of the surveys.