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Evidence-based recommendations on the use of intravenous lipid emulsion therapy in poisoning*
TLDR
Clinical recommendations regarding the use of ILE in poisoning were only possible in a small number of scenarios and were based mainly on very low quality of evidence, balance of expected risks and benefits, adverse effects, laboratory interferences as well as related costs and resources. Expand
Characterization of 4-aminopyridine in overdose.
TLDR
Three patients on therapeutic regimens for the treatment of multiple sclerosis were reported to have taken 4-aminopyridine overdose resulting in seizure activity, although the length of toxicity was prolonged more than 24 hours in one patient. Expand
Emergency department treatment of viral gastritis using intravenous ondansetron or dexamethasone in children.
TLDR
In children with dehydration secondary to vomiting from acute viral gastritis, ondansetron with intravenous rehydration improves tolerance of oral fluids after two hours and reduces the hospital admission rate when compared with intravenously rehydrations with or without dexamethasone. Expand
Multicenter Case Series of Pediatric Metformin Ingestion
TLDR
Unintentional ingestion of ≤1700 mg of metformin in the healthy pediatric population does not appear to pose a significant health risk of hypoglycemia or detrimental outcome. Expand
Pharmacokinetics following a loading plus a continuous infusion of pralidoxime compared with the traditional short infusion regimen in human volunteers.
TLDR
It is indicated that a loading dose followed by a continuous infusion of pralidoxime maintains therapeutic concentrations for a longer period of time than the currently recommended short infusion regimen in healthy volunteers. Expand
Systematic review of the effect of intravenous lipid emulsion therapy for non-local anesthetics toxicity
TLDR
The effect of ILE in various non-local anesthetic poisonings is heterogenous, and the quality of evidence remains low to very low. Expand
Diethylene glycol: widely used solvent presents serious poisoning potential.
TLDR
A case of intentional ingestion of a wallpaper stripper containing DEG resulting in severe multi-system organ failure and severe neurologic sequelae is described, demonstrating the severe toxicity of DEG. Expand
Severe Hyperphosphatemia and Hypocalcemia Following the Rectal Administration of a Phosphate-Containing Fleet® Pediatric Enema
TLDR
Osmotically acting hypertonic phosphate enemas can result in severe toxicity if retained even in patients without predisposing risk factors, especially in patients with normal renal function. Expand
Pediatric toxicologic concerns.
TLDR
Clinician skills in identifying toxidromes and important physical examination findings can enable the clinician to determine who is at risk for significant morbidity or mortality and to provide the appropriate medical care. Expand
Home observation for asymptomatic coin ingestion: acceptance and outcomes. The New York State Poison Control Center Coin Ingestion Study Group.
TLDR
Although all of the 67 children managed by home observation did well, most of their caretakers had not accepted this management strategy, and a prospective study of home observation for asymptomatic pediatric coin ingestion would be safe and allow further examination of factors affecting acceptance. Expand
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