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Community-acquired pneumonia requiring hospitalization among U.S. children.
TLDR
The burden of hospitalization for children with community-acquired pneumonia was highest among the very young, with respiratory viruses the most commonly detected causes of pneumonia. Expand
Seasonality of Acute Otitis Media and the Role of Respiratory Viral Activity in Children
TLDR
Seasonal respiratory syncytial virus, human metapneumovirus and influenza activity were temporally associated with increased diagnoses of AOM among children and support the role of individual respiratory viruses in the development of acute otitis media. Expand
Use of Methylxanthine Therapies for the Treatment and Prevention of Apnea of Prematurity
TLDR
This review of the literature on neonatal methylxanthine therapies found that caffeine is associated with fewer adverse effects and a wider therapeutic window when compared with theophylline, and larger doses of caffeine citrate have been shown to improve acute neonatal outcomes when administered promptly. Expand
Respiratory Viral Detection in Children and Adults: Comparing Asymptomatic Controls and Patients With Community-Acquired Pneumonia
TLDR
Detections of influenza, respiratory syncytial virus, and human metapneumovirus among patients with CAP of all ages probably indicate an etiologic role, whereas detections of parainfluenza, coronaviruses, rhinovirus, and adenovirus require further scrutiny. Expand
Community Surveillance of Respiratory Viruses Among Families in the Utah Better Identification of Germs-Longitudinal Viral Epidemiology (BIG-LoVE) Study
TLDR
Viral detection is frequently asymptomatic and occasionally lasts ≥3 weeks, particularly with bocavirus and rhinovirus, and these data warrant consideration when interpreting polymerase chain reaction results in the clinical setting. Expand
Taxonomer: an interactive metagenomics analysis portal for universal pathogen detection and host mRNA expression profiling
TLDR
It is shown that Taxonomer detects previously unrecognized infections and reveals antiviral host mRNA expression profiles and enables rapid, accurate, and interactive analyses of metagenomics data on personal computers and mobile devices. Expand
Optimization of anti‐pseudomonal antibiotics for cystic fibrosis pulmonary exacerbations: II. cephalosporins and penicillins
TLDR
The need to optimize antibiotic dosing and dosing regimens used to treat an APE in efforts to improve outcomes for CF patients infected with Pseudomonas aeruginosa is suggested. Expand
Activation of Transient Receptor Potential Ankyrin-1 by Insoluble Particulate Material and Association with Asthma.
TLDR
Roles for ankyrin domain-4, cell surface N-linked glycans, and selected pore-loop domain residues in the activation of TRPA1 by insoluble particles are identified and suggested to modulate asthma, particularly among individuals living in locations prone to high levels of air pollution. Expand
Incidence, Morbidity, and Costs of Human Metapneumovirus Infection in Hospitalized Children.
TLDR
The development of a safe and effective vaccine could reduce the clinical and economic burden of HMPV, which results in a large number of hospitalizations with substantial morbidity, resource utilization, and costs. Expand
Optimization of anti‐pseudomonal antibiotics for cystic fibrosis pulmonary exacerbations: V. Aminoglycosides
TLDR
An evidence‐based summary of pharmacokinetic/pharmacodynamic, tolerability, and efficacy studies utilizing IV amikacin, gentamicin, and tobramycin in the treatment of APE is provided to highlight areas where further investigation is needed. Expand
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