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The La-Related Proteins, a Family with Connections to Cancer
The evolutionarily-conserved La-related protein (LARP) family currently comprises Genuine La, LARP1, LARP1b, LARP4, LARP4b, LARP6 and LARP7. Emerging evidence suggests each LARP has a distinct role… Expand
A study of symptoms described by ovarian cancer survivors.
OBJECTIVE A cross-sectional, observational study to evaluate physical and psychological symptoms experienced by patients following completion of treatment for ovarian cancer and compared to symptoms… Expand
Risk of Ovarian Cancer Relapse Score
- I. Rizzuto, C. Stavraka, +6 authors S. Blagden
- International Journal of Gynecologic Cancer
- 7 December 2014
Objective The aim of this study was to construct a prognostic index that predicts risk of relapse in women who have completed first-line treatment for ovarian cancer (OC). Methods A database of OC… Expand
A study to evaluate the cause of bone demineralization in gynecological cancer survivors.
BACKGROUND An association between treatment for gynecological cancers and risk of osteoporosis has never been formally evaluated. Women treated for these cancers are now living longer than ever… Expand
Sexual activity and functioning in ovarian cancer survivors: an internet-based evaluation
- T. G. Hopkins, C. Stavraka, H. Gabra, L. Fallowfield, C. Hood, S. Blagden
- Climacteric : the journal of the International…
- 2 January 2015
Abstract Objectives Sexual dysfunction is a known complication of treatment for many cancers, but there have been relatively few studies investigating outcomes for ovarian cancer survivors. We have… Expand
First-in-Human Study of CH5132799, an Oral Class I PI3K Inhibitor, Studying Toxicity, Pharmacokinetics, and Pharmacodynamics, in Patients with Metastatic Cancer
Purpose: This phase I dose-escalation study investigated the maximum-tolerated dose (MTD), dose-limiting toxicities (DLT), safety, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary… Expand
Combined hepatocellular cholangiocarcinoma (cHCC-CC): an update of genetics, molecular biology, and therapeutic interventions
Combined hepatocellular cholangiocarcinoma (CC) is a rare and aggressive primary hepatic malignancy with significant histological and biological heterogeneity. It presents with more aggressive… Expand
An Inflammation Based Score Can Optimize the Selection of Patients with Advanced Cancer Considered for Early Phase Clinical Trials
Background Adequate organ function and good performance status (PS) are common eligibility criteria for phase I trials. As inflammation is pathogenic and prognostic in cancer we investigated the… Expand
Final results of ProGem1, the first in-human phase I/II study of NUC-1031 in patients with solid malignancies.
2514 Background: NUC-1031 is a first-in-class nucleotide analogue utilising phosphoramidate chemistry to enhance anti-cancer efficacy and safety. In preclinical studies NUC-1031 demonstrated potent… Expand
Palbociclib and endocrine therapy in heavily pretreated hormone receptor-positive HER2-negative advanced breast cancer: the UK Compassionate Access Programme experience
- N. Battisti, B. Kingston, +17 authors S. Johnston
- Breast Cancer Research and Treatment
- 17 January 2019
PurposePalbociclib is approved in 1st line for hormone receptor (HR)-positive HER2-negative advanced breast cancer (ABC). A Compassionate Access Programme previously allowed patients to receive it in… Expand