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Pharmacokinetics of sulphinpyrazone and its major metabolites after a single dose and during chronic treatment
SummaryThe pharmacokinetics of sulphinpyrazone and its major metabolites (sulfide, sulfone, p-hydroxysulfone and p-hydroxy-sulphinpyrazone) were investigated in 9 volunteers after a single oral doseExpand
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Inhibition of drug metabolism by the antimalarial drugs chloroquine and primaquine in the rat.
Abstract The effect of the antimalarial drugs chloroquine (CQ) and primaquine (PQ) on rat liver microsomal drug metabolism has been studied in vitro and in vivo . After acute administration, PQExpand
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Comparative effects of famotidine and cimetidine on antipyrine kinetics in healthy volunteers.
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Induction of drug metabolizing enzymes by sulfinpyrazone
SummaryA previous interaction study of sulfinpyrazone (Anturano®) suggested that it induced microsomal drug metabolizing enzymes in the liver. To verify this finding the effect of sulfinpyrazone 800Expand
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The effects of ampicillin on oral contraceptive steroids in women.
1 Thirteen women taking long term oral contraceptive steroids were studied while taking ampicillin (500 mg three times daily) and compared to a control cycle while not taking ampicillin. 2 There wereExpand
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Effect of single and multiple doses of sulphinpyrazone on antipyrine metabolism and urinary excretion of 6-beta-hydroxycortisol
SummarySulphinpyrazone decreases the plasma clearance of tolbutamide and S-warfarin and increases the clearance of R-warfarin, theophylline and antipyrine. In order to determine whetherExpand
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Cimetidine does not increase the anticoagulant effect of phenprocoumon.
In patients on oral warfarin, nicoumalone and phenindione an increase of the anticoagulant effect has been described during concomitant treatment with cimetidine. Therefore we have investigated theExpand
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[Effect of metronidazole on phenazone metabolism].
Nine volunteers received in random order on three occasions either 15 mg/kg phenazone (antipyrine; in the following called phenazone, INN), 15 mg/kg phenazone and 1000 mg cimetidine or 15 mg/kgExpand
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