C. Spenger

Publications18
h-index13
Citations1,181
Highly Influential Citations43
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Tau protein in cerebrospinal fluid: a biochemical marker for axonal degeneration in Alzheimer disease?
Cerebrospinal fluid (CSF) biochemical markers for Alzheimer disease (AD) would be of great value to improve the clinical diagnostic accuracy of the disorder. As abnormally phosphorylated forms of the… Expand
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Automated Hippocampal Subfield Measures as Predictors of Conversion from Mild Cognitive Impairment to Alzheimer’s Disease in Two Independent Cohorts
Previous studies have shown that hippocampal subfields may be differentially affected by Alzheimer’s disease (AD). This study used an automated analysis technique and two large cohorts to (1)… Expand
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Education increases reserve against Alzheimer’s disease—evidence from structural MRI analysis
IntroductionThe aim of this study was to determine whether years of schooling influences regional cortical thicknesses and volumes in Alzheimer’s disease (AD), mild cognitive impairment (MCI), and… Expand
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Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease
Alzheimer's disease (AD) is a progressive neurodegenerative disorder with considerable evidence suggesting an initiation of disease in the entorhinal cortex and hippocampus and spreading thereafter… Expand
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In vivo 1H-magnetic resonance spectroscopy can detect metabolic changes in APP/PS1 mice after donepezil treatment
BackgroundDonepezil improves cognitive functions in AD patients. Effects on the brain metabolites N-acetyl-L-aspartate, choline and myo- inositol levels have been reported in clinical studies using… Expand
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Predicting resistance or response to chemotherapy by proton magnetic resonance spectroscopy in neuroblastoma.
BACKGROUND We previously showed that proton magnetic resonance spectroscopy (1H-MRS) enables estimation of neuroblastoma tumor viability. Here we investigated if 1H-MRS can predict response or… Expand
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Kv1.1 null mice have enlarged hippocampus and ventral cortex
BackgroundMutations in the Shaker-like voltage-gated potassium channel Kv1.1 are known to cause episodic ataxia type 1 and temporal lobe epilepsy. Mice that express a malfunctional, truncated Kv1.1… Expand
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Noninvasive estimation of tumour viability in a xenograft model of human neuroblastoma with proton magnetic resonance spectroscopy (1H MRS)
The aim of the study was to evaluate proton magnetic resonance spectroscopy (1H MRS) for noninvasive biological characterisation of neuroblastoma xenografts in vivo. For designing the experiments,… Expand
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Fluorine-18 labeling of three novel D-peptides by conjugation with N-succinimidyl-4-[18F]fluorobenzoate and preliminary examination by postmortem whole-hemisphere human brain autoradiography.
INTRODUCTION β-Amyloid (Aβ) plaques and neurofibrillary tangles are the main characteristics of Alzheimer's disease (AD). Positron emission tomography (PET), a high-resolution, sensitive, and… Expand
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Carbamazepine treatment recovered low N-acetylaspartate+N-acetylaspartylglutamate (tNAA) levels in the megencephaly mouse BALB/cByJ-Kv1.1mceph/mceph
Megencephaly mice (BALB/cByJ-Kv1.1(mceph/mceph)) display excessive brain growth and seizures related to a mutation within the potassium channel gene Kv1.1 producing a malfunctioning protein. (1)H… Expand
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