• Publications
  • Influence
Osteoporosis and venous thromboembolism: a retrospective cohort study in the UK General Practice Research Database
A greater association of venous thromboembolism (VTE) in osteoporotic compared to non-osteoporosis patients is shown, but does not show any greater association in treated patients with strontium ranelate or alendronate compared to untreated osteop orotic patients. Expand
Perindopril postmarketing surveillance: a 12 month study in 47,351 hypertensive patients.
This study successfully followed a large cohort of patients treated with perindopril and failed to demonstrate any unexpected hazards. Expand
Drug rash with eosinophilia and systemic symptoms (DRESS) in patients receiving strontium ranelate
DRESS is a well-identified and characterised adverse reaction to strontium ranelate and should be integrated in the risk-benefit balance evaluation of patient treatment, and the occurrence of a rash should lead to prompt and permanent treatment discontinuation with careful follow-up. Expand
Quinidine and the identification of drugs whose elimination is impaired in subjects classified as poor metabolizers of debrisoquine.
The effects of quinidine at a dose of only 50 mg, on the metabolism of a new drug in EM subjects may prove a useful method of assessing the contribution of the debrisoquine 4-hydroxylase isozyme to the elimination of the drug tested. Expand
Postmarketing surveillance of enalapril. I: Results of prescription-event monitoring.
Enalapril was considered to be effective, even in patients with advanced cardiac failure, and the notes of 913 of them were obtained for detailed scrutiny, providing further evidence of the value of prescription-event monitoring. Expand
Postmarketing surveillance of enalapril. II: Investigation of the potential role of enalapril in deaths with renal failure.
Enalapril infrequently contributed to a substantial decline in renal function in certain vulnerable patients, especially those receiving other drugs known to be capable of adversely affecting renal function, and awareness of the characteristics of these patients and of their concomitant treatment may serve to reduce the risk. Expand
The effectiveness of external beam radiotherapy for acromegaly is not affected by previous pituitary ablative treatments.
It appears that radiotherapy is equally efficacious whether a prior unsuccessful ablative procedure had been used or not and requirement for pituitary hormone replacement therapy increased from 15 patients before radiotherapy to 20 after radiotherapy, being mostly those who had had prior ablative therapies. Expand
Debrisoquine oxidation phenotype and susceptibility to lung cancer.
It is concluded that debrisoquine metabolic phenotype is not a good predictor of risk of developing lung cancer in the population at large. Expand
Comparison of the Safety of Several Nonsteroidal Anti‐inflammatory Drugs Currently or Formerly Marketed in the United Kingdom
  • C. Speirs
  • Medicine
  • Journal of clinical pharmacology
  • 1 December 1988
It is concluded that anomalies in the frequency and pattern of suspected drug‐related adverse reactions in the absence of any confounding factor are an important signal of the need for further investigation. Expand