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LRRK2 mutations on Crete: R1441H associated with PD evolving to PSP
Mutations of the LRRK2 gene that encodes the protein dardarin occur in Parkinson disease (PD)1 with the G2019S change being the most common cause of hereditary parkinsonism. While the G2019S mutationExpand
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Rising incidence of multiple sclerosis in females associated with urbanization
Objective: To design and perform a case-control study of multiple sclerosis (MS) in Crete, an island of 0.6 million people, that has experienced profound socioeconomic changes in recent decades.Expand
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Human GLUD2 Glutamate Dehydrogenase Is Expressed in Neural and Testicular Supporting Cells*
Mammalian glutamate dehydrogenase (GDH) is an allosterically regulated enzyme that is expressed widely. Its activity is potently inhibited by GTP and thought to be controlled by the need of the cellExpand
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Molecular basis of human glutamate dehydrogenase regulation under changing energy demands
Glutamate dehydrogenase (GDH), an enzyme central to glutamate metabolism, is located in the mitochondria although there is evidence for extramitochondrial localization of GDH. In the human,Expand
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The Role of Glutamate Dehydrogenase in Mammalian Ammonia Metabolism
Glutamate dehydrogenase (GDH) catalyzes the reversible inter-conversion of glutamate to α-ketoglutarate and ammonia. High levels of GDH activity is found in mammalian liver, kidney, brain, andExpand
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Expression of human GLUD2 glutamate dehydrogenase in human tissues: Functional implications
Glutamate dehydrogenase (GDH), a mitochondrial enzyme with a key metabolic role, exists in the human in hGDH1 and hGDH2 isoforms encoded by the GLUD1 and GLUD2 genes, respectively. It seems thatExpand
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Estrogen Modification of Human Glutamate Dehydrogenases Is Linked to Enzyme Activation State*
Mammalian glutamate dehydrogenase (GDH) is a housekeeping enzyme central to the metabolism of glutamate. Its activity is potently inhibited by GTP (IC50 = 0.1–0.3 μm) and thought to be controlled byExpand
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Essential tremor in Parkinson's disease kindreds from a population of similar genetic background
To investigate the possible association between essential tremor (ET) and Parkinson's disease (PD) we conducted a prospective clinical and epidemiological study in a population of similar geneticExpand
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Deregulation of glutamate dehydrogenase in human neurologic disorders
Mammalian glutamate dehydrogenase is an allosterically regulated enzyme that is central to glutamate metabolism. It contributes to important cellular processes, including Krebs cycle anapleroticExpand
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Widening Spectrum of Cellular and Subcellular Expression of Human GLUD1 and GLUD2 Glutamate Dehydrogenases Suggests Novel Functions
Mammalian glutamate dehydrogenase1 (GDH1) (E.C. is a mitochondrial enzyme that catalyzes the reversible oxidative deamination of glutamate to α-ketoglutarate and ammonia while reducing NAD+Expand
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