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- Publications
- Influence
Pharmacological analysis of cyclooxygenase-1 in inflammation.
- C. Smith, Y. Zhang, +7 authors P. Isakson
- Chemistry, Medicine
- Proceedings of the National Academy of Sciences…
- 27 October 1998
The enzymes cyclooxygenase-1 and cyclooxygenase-2 (COX-1 and COX-2) catalyze the conversion of arachidonic acid to prostaglandin (PG) H2, the precursor of PGs and thromboxane. These lipid mediators… Expand
An international literature survey of "IARC Group I carcinogens" reported in mainstream cigarette smoke.
- C. Smith, S. Livingston, D. Doolittle
- Chemistry, Medicine
- Food and chemical toxicology : an international…
- 1 October 1997
The International Agency for Research on Cancer (IARC) currently lists 44 individual chemical agents, 12 groups or mixtures of chemicals and 13 exposure circumstances as "Group 1 human carcinogens".… Expand
The relative toxicity of compounds in mainstream cigarette smoke condensate.
Many different in vivo and in vitro tests are currently used to assess the toxicity of chemicals and complex mixtures such as cigarette smoke condensate. In vivo tests include assays in rodents to… Expand
"IARC group 2A Carcinogens" reported in cigarette mainstream smoke.
- C. Smith, T. A. Perfetti, M. A. Rumple, A. Rodgman, D. Doolittle
- Chemistry, Medicine
- Food and chemical toxicology : an international…
- 1 September 2000
As a follow-up to an earlier study on IARC Group I compounds, further efforts have been made to evaluate the international literature on cigarette mainstream smoke for reports on constituents… Expand
Particulate and vapor phase constituents of cigarette mainstream smoke and risk of myocardial infarction.
- C. Smith, T. H. Fischer
- Medicine
- Atherosclerosis
- 1 October 2001
On pharmacological and compositional grounds, cigarette mainstream smoke (MS) aerosol can be broadly categorized as consisting of the following constituents: carbon monoxide, other vapor phase… Expand
Binding of a chaperonin to the folding intermediates of lactate dehydrogenase.
- I. G. Badcoe, C. Smith, +4 authors A. Clarke
- Chemistry, Medicine
- Biochemistry
- 24 September 1991
When Bacillus stearothermophilus LDH dimer is incubated with increasing concentrations of the denaturant guanidinium chloride, three distinct unfolded states of the molecule are observed at… Expand
Molecular cloning and expression of human myocardial cGMP-inhibited cAMP phosphodiesterase.
- E. Meacci, M. Taira, +5 authors V. Manganiello
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 1 May 1992
We have cloned a cDNA for a myocardial cGMP-inhibited cAMP phosphodiesterase (cGI PDE) from a human heart cDNA library in lambda Zap II. The open reading frame [3.5 kilobases (kb)] of cDNA clone… Expand
IARC carcinogens reported in cigarette mainstream smoke and their calculated log P values.
- C. Smith, T. A. Perfetti, R. Garg, C. Hansch
- Chemistry, Medicine
- Food and chemical toxicology : an international…
- 1 June 2003
Cigarette smoke is a complex aerosol of minute liquid droplets (termed the particulate phase) suspended within a mixture of gases (CO(2), CO, NO(x), etc.) and semi-volatile compounds. The… Expand
Hormone-sensitive cyclic GMP-inhibited cyclic AMP phosphodiesterase in rat adipocytes. Regulation of insulin- and cAMP-dependent activation by phosphorylation.
- C. Smith, V. Vasta, E. Degerman, P. Belfrage, V. Manganiello
- Medicine, Biology
- The Journal of biological chemistry
- 15 July 1991
In 32PO4-labeled adipocytes, isoproterenol (ISO) or physiologically relevant concentrations of insulin rapidly increased phosphorylation of a particulate 135-kDa protein which has been identified as… Expand
QSAR treatment of multiple toxicities: the mutagenicity and cytotoxicity of quinolines.
- C. Smith, C. Hansch, M. J. Morton
- Chemistry, Medicine
- Mutation research
- 6 October 1997
A series of 15 quinoline congeners were assayed for mutagenicity and cytotoxicity in the Ames test using strain TA100 bacteria. Statistical analysis of the data allowed simultaneous determination of… Expand