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Scanning and competition between AGs are involved in 3' splice site selection in mammalian introns.
In mammalian intron splicing, the mechanism by which the 3' splice site AG is accurately and efficiently identified has remained unresolved. We have previously proposed that the 3' splice site in… Expand
Polypyrimidine Tract Binding Protein Functions as a Repressor To Regulate Alternative Splicing of α-Actinin Mutally Exclusive Exons
ABSTRACT The smooth muscle (SM) and nonmuscle (NM) isoforms of α-actinin are produced by mutually exclusive splicing of an upstream NM exon and a downstream SM-specific exon. A rat α-actinin genomic… Expand
Processing of the Human Heparanase Precursor and Evidence That the Active Enzyme Is a Heterodimer*
- M. Fairbanks, A. Mildner, +8 authors R. Heinrikson
- Medicine, Chemistry
- The Journal of Biological Chemistry
- 15 October 1999
Human platelet heparanase has been purified to homogeneity and shown to consist of two, non-covalently associated polypeptide chains of molecular masses 50 and 8 kDa. Protein sequencing provided the… Expand
The coronin-like protein POD-1 is required for anterior-posterior axis formation and cellular architecture in the nematode caenorhabditis elegans.
- C. Rappleye, A. Paredez, C. Smith, K. L. McDonald, R. Aroian
- Biology, Medicine
- Genes & development
- 1 November 1999
Establishment of anterior-posterior (a-p) polarity in the Caenorhabditis elegans embryo depends on filamentous (F-) actin. Previously, we isolated an F-actin-binding protein that was enriched in the… Expand
Diversity of Vertebrate Splicing Factor U2AF35
- T. Pacheco, A. Gomes, +6 authors M. Carmo-Fonseca
- Biology, Medicine
- Journal of Biological Chemistry
- 25 June 2004
U2 small nuclear ribonucleoprotein auxiliary factor small subunit (U2AF35) is encoded by a conserved gene designated U2AF1. Here we provide evidence for the existence of alternative vertebrate… Expand
Co-transcriptional commitment to alternative splice site selection.
- G. C. Roberts, C. Gooding, H. Y. Mak, N. Proudfoot, C. Smith
- Medicine, Biology
- Nucleic acids research
- 15 December 1998
Production of mRNA in eukaryotic cells involves not only transcription but also various processing reactions such as splicing. Recent experiments have indicated that there are direct physical… Expand
Differential alternative splicing activity of isoforms of polypyrimidine tract binding protein (PTB).
- M. Wollerton, C. Gooding, F. Robinson, E. Brown, R. Jackson, C. Smith
- Biology, Medicine
- 1 June 2001
Polypyrimidine tract binding protein (PTB) is an RNA-binding protein that regulates splicing by repressing specific splicing events. It also has roles in 3'-end processing, internal initiation of… Expand
Alternative splicing in the control of gene expression.
In this review, we focus upon the mechanistic, functional, and evolutionary aspects of alternative splicing. The discussion of mechanisms attempts to be exhaustive, drawing not only upon direct… Expand
The mechanism of Ca2+ regulation of vascular smooth muscle thin filaments by caldesmon and calmodulin.
- C. Smith, K. Pritchard, Steven B Marston
- Chemistry, Medicine
- The Journal of biological chemistry
- 5 January 1987
The interactions of vascular smooth muscle caldesmon with actin, tropomyosin, and calmodulin were determined under conditions in which the four proteins can form reconstituted Ca2+-sensitive smooth… Expand
ElAM: A computer program for the analysis and representation of anisotropic elastic properties
- A. Marmier, Zoe A. D. Lethbridge, R. Walton, C. Smith, S. Parker, K. Evans
- Mathematics, Computer Science
- Comput. Phys. Commun.
- 1 December 2010
The continuum theory of elasticity has been used for more than a century and has applications in many fields of science and engineering. Expand