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Antimicrobial activity against Staphylococcus aureus of semisynthetic injectable streptogramins: RP 59500 and related compounds.
- J. Barrière, D. Bouanchaud, J. Paris, O. Rolin, N. Harris, C. Smith
- Chemistry, BiologyThe Journal of antimicrobial chemotherapy
In-vitro and in-vivo activities of some representative water-soluble derivatives of pristinamycin IA and prist inamycin IIA against Staphylococcus aureus reference strains, sensitive or resistant to methicillin and/or macrolides are reported.
In Vitro Studies of the Combined Effect of Ampicillin and Sulfonamides on Nocardia asteroides and Results of Therapy in Four Patients
- M. Orfanakis, H. Wilcox, C. Smith
- Medicine, BiologyAntimicrobial Agents and Chemotherapy
- 1 March 1972
Combined therapy with ampicillin and sulfonamides was used in four immunologically suppressed renal transplant patients who had pulmonary infection with N. asteroides and the disease was arrested in two patients who were maintained on full immunosuppressive therapy.
The Chemistry of Pristinamycins
Up to the appearance of high-field NMR there was no efficient analytical method for structure confirmation of pristinamycin derivatives, and relatively few studies have been devoted to semi-synthetic modification of these compounds for reasons of chemical instability.
Antifungal properties in a novel series of triazino[5,6-b]indoles
- O. Kinsman, D. Livermore, C. Smith
- Biology, MedicineAntimicrobial Agents and Chemotherapy
- 1 June 1993
GR99060 was efficacious in a murine model of systemic candidiasis by oral or parenteral administration, although no clear dose-response was achieved, suggesting that other factors adversely affected the compound's in vivo activity.
Effect of morphine or phenobarbital on teicoplanin elimination pharmacokinetics.
- P. Fan-Havard, Z. Koshy, R. Bais, C. Smith, R. Eng
- Medicine, BiologyThe Journal of antimicrobial chemotherapy
- 1 July 1993
A significant increase in the total clearance of teicoplanin was found in rats pre-treated with MS as compared to controls, and can best be explained by an increase in both renal elimination and hepatic metabolic pathways.