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Gut hormone PYY3-36 physiologically inhibits food intake
Peripheral injection of PYY3-36 in rats inhibits food intake and reduces weight gain and suggests that the anorectic effect requires the Y2R, a putative inhibitory presynaptic receptor in the arcuate nucleus of the hypothalamus. Expand
Ghrelin causes hyperphagia and obesity in rats.
Evidence is provided that ghrelin is important in long-term control of food intake and body weight and that circulating gh Relin at fasting concentrations may stimulate food intake. Expand
AMP-activated Protein Kinase Plays a Role in the Control of Food Intake*
- U. Andersson, K. Filipsson, +5 authors C. Small
- Biology, Medicine
- Journal of Biological Chemistry
- 26 March 2004
It is demonstrated that counter-regulatory hormones involved in appetite control regulate AMPK activity and that pharmacological activation of AMPK in the hypothalamus increases food intake, and that AMPK is identified as a novel target for anti-obesity drugs. Expand
The inhibitory effects of peripheral administration of peptide YY3–36 and glucagon-like peptide-1 on food intake are attenuated by ablation of the vagal–brainstem–hypothalamic pathway
Findings suggest that the vagal-brainstem-hypothalamic pathway may also play a role in the effects of circulating PYY(3-36) and GLP-1 on food intake. Expand
The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion.
It is found that both intracerebroventricular and intraperitoneal administration of ghrelin in freely feeding rats stimulated food intake and plasma growth hormone (GH) concentration increased following both i.c.v. and i.p. administration. Expand
A C-terminal fragment of Agouti-related protein increases feeding and antagonizes the effect of alpha-melanocyte stimulating hormone in vivo.
Agrp(83-132) administered i.c.v. increases feeding with long lasting effects and is able to inhibit the action of alphaMSH, which may be mediated by the MC3-R and/or MC4-R. Expand
Gastrointestinal hormones regulating appetite
- O. Chaudhri, C. Small, S. Bloom
- Biology, Medicine
- Philosophical Transactions of the Royal Society B…
- 29 July 2006
The role of gastrointestinal hormones in the regulation of appetite is reviewed, and the dual role exhibited by many gut peptides as both hormones and neurotransmitters is reflected. Expand
Peripheral oxyntomodulin reduces food intake and body weight gain in rats.
It is reported that peripheral (ip) administration of OXM dose-dependently inhibited both fast-induced and dark-phase food intake without delaying gastric emptying and there was a significant increase in c-fos immunoreactivity in the arcuate nucleus (ARC). Expand
Blockade of the neuropeptide Y Y2 receptor with the specific antagonist BIIE0246 attenuates the effect of endogenous and exogenous peptide YY(3–36) on food intake
The studies suggest that the Y2R plays an important role in post-prandial satiety and provide further insight into the mechanisms of action of PYY, hypothesised to inhibit food intake via activation of the auto-inhibitory pre-synaptic neuropeptide Y (NPY) Y2 receptor (Y2R). Expand
Oxyntomodulin inhibits food intake in the rat.
It is reported that oxyntomodulin inhibits refeeding when injected intracerebroventricularly and into the hypothalamic paraventricular nucleus of 24-h fasted rats and was blocked when it was coadministered with the glucagon-like peptide-1 receptor antagonist, exendin-(9-39). Expand