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Igh-6−/−(B-Cell-Deficient) Mice Fail To Mount Solid Acquired Resistance to Oral Challenge with Virulent Salmonella enterica Serovar Typhimurium and Show Impaired Th1 T-Cell Responses toSalmonella
ABSTRACT In the present study we evaluated the role of B cells in acquired immunity to Salmonella infection by using gene-targeted B-cell-deficient innately susceptible mice on a C57BL/6 backgroundExpand
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Does confirmatory tumor biopsy alter the management of breast cancer patients with distant metastases?
Background: Decisions about systemic treatment of women with metastatic breast cancer are often based on estrogen receptor (ER), progesterone receptor (PgR), and Her2 status of the primary tumor.Expand
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Are Estring® and Vagifem® equally effective and safe for the treatment of urogenital atrophy in breast cancer patients on aromatase inhibitor therapy?
Sir d The urogenital side-effects of aromatase inhibitors are well recognised, and can have a significant negative effect on quality of life. Safety issues around the use of oestrogen-based therapiesExpand
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A phase 2 trial exploring the effects of high‐dose (10,000 IU/day) vitamin D3 in breast cancer patients with bone metastases
Vitamin D deficiency has potential roles in breast cancer etiology and progression. Vitamin D deficiency has also been associated with increased toxicity from bisphosphonate therapy. The optimal doseExpand
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A randomized phase II study of weekly paclitaxel with or without pelareorep in patients with metastatic breast cancer: final analysis of Canadian Cancer Trials Group IND.213.
BackgroundPelareorep, a serotype 3 reovirus, has demonstrated preclinical and early clinical activity in breast cancer and synergistic cytotoxic activity with microtubule targeting agents. ThisExpand
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Is knowledge translation adequate? A quality assurance study of staging investigations in early stage breast cancer patients
After primary surgery, patients diagnosed with early stage breast cancer undergo radiological investigations based on pathologic stage of disease to rule out distant metastases. Published guidelinesExpand
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Impact of new chemotherapeutic and targeted agents on survival in stage IV non-small cell lung cancer.
e18015 Background: Significant advances in the systemic management of metastatic non-small cell lung cancer (NSCLC) have occurred over the past decade, with options now including multiple lines ofExpand
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Comparison of international breast cancer guidelines: are we globally consistent? cancer guideline AGREEment.
BACKGROUND Evidence-based guidelines are used in health care systems throughout the world to aid in treatment decisions and to ensure quality and consistency in patient care. In breast oncology,Expand
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A Canadian national expert consensus on neoadjuvant therapy for breast cancer: linking practice to evidence and beyond.
BACKGROUND Use of the neoadjuvant approach to treat breast cancer patients has increased since the early 2000s, but the overall pathway of care for such patients can be highly variable. The aim ofExpand
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Impact of new chemotherapeutic and targeted agents on survival in stage IV non-small cell lung cancer.
PURPOSE Significant advances in the systemic management of metastatic non-small cell lung cancer (NSCLC) have occurred over the past decade, with options now including multiple lines of chemotherapy,Expand
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