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ATP acts as a survival signal and prevents the mineralization of aortic valve.
TLDR
It is shown that bioavailability of extracellular ATP is a signal which determines survival or apoptosis of VICs and, in doing so, plays a major role in the development of CAVD. Expand
Unusual Effects of a QT-Prolonging Drug, Arsenic Trioxide, on Cardiac Potassium Currents
TLDR
It is inferred that variability in the extent of QT interval prolongation and onset of ventricular arrhythmias during arsenic therapy represents competing effects to block and activate multiple repolarizing potassium currents. Expand
An improved HPLC assay with fluorescence detection for the determination of domperidone and three major metabolites for application to in vitro drug metabolism studies.
TLDR
The assay allows estimation of enzymatic parameters (K(m) and V(max) of domperidone for the formation of its various metabolites and sensitivity is sufficient for the conduct of inhibition studies with potent CYP3A inhibitors. Expand
Human cardiac potassium channel DNA polymorphism modulates access to drug-binding site and causes drug resistance.
TLDR
Assessing drug sensitivity of I(Kur) generated in vitro in CHO and HEK cells by channels predicted to exhibit or lack this C-terminal alpha-helix found that this secondary structure in the KCNA5 C terminus does not alter baseline currents but renders the channel drug resistant. Expand
Modulation of CYP3a expression and activity in mice models of type 1 and type 2 diabetes
TLDR
The results suggest that these two distinct diseases may have the same modulating effect on the regulation of CYP3a, ultimately leading to variability in drug response, ranging from lack of effect to life‐threatening toxicity. Expand
Decreased CYP3A Expression and Activity in Guinea Pig Models of Diet-Induced Metabolic Syndrome: Is Fatty Liver Infiltration Involved?
TLDR
Diet-induced metabolic syndrome decreases CYP3A expression/activity in guinea pigs, which may ultimately lead to variability in drug response, ranging from lack of effect to life-threatening toxicity. Expand
Identification of the cytochrome P450 enzymes involved in the metabolism of domperidone
TLDR
The data suggest that CYP3As are the major enzymes involved in the metabolism of domperidone. Expand
Prolongation of Cardiac Ventricular Repolarization Under Paliperidone: How and How Much?
TLDR
Paliperidone prolongs the QT interval by blocking HERG current at clinically relevant concentrations and is potentially unsafe. Expand
Polymorphism Screening in the Cardiac K+ Channel Gene KCNA5
TLDR
This study screened an additional gene encoding the cardiac potassium channel KCNA5 (underlying IKur) in 3 ethnic groups and evaluated the functional consequences of the variants identified. Expand
QRS widening and QT prolongation under bupropion: a unique cardiac electrophysiological profile
TLDR
FRAP experiments confirmed that bupropion inhibits gap junctional intercellular communication and mimics the QRS‐widening, MAP amplitude‐ and phase 0 dV/dt ‐reducing effect of glycyrrhetinic acid and heptanol. Expand
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