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Gene expression profiling of human endometrial receptivity on days LH+2 versus LH+7 by microarray technology.
TLDR
Gene expression profiles of pre-receptive versus receptive endometria obtained from the same fertile woman in the same menstrual cycle are compared to gain a global molecular understanding of human endometrial receptivity. Expand
Circulating progesterone levels and ongoing pregnancy rates in controlled ovarian stimulation cycles for in vitro fertilization: analysis of over 4000 cycles.
TLDR
Evaluated patients undergoing IVF/ICSI cycles using gonadotrophin-releasing hormone (GnRH) analogues for pituitary down-regulation found elevated serum progesterone levels on the day of hCG administration is associated with reduced ongoing pregnancy rates. Expand
A genomic diagnostic tool for human endometrial receptivity based on the transcriptomic signature.
TLDR
A genomic tool composed of a customized microarray and a bioinformatic predictor for endometrial dating and to detect pathologies ofendometrial origin can be used clinically in reproductive medicine and gynecology and the transcriptomic signature is a potential endometrian receptivity biomarkers cluster. Expand
Leptin and reproduction.
TLDR
It is postulate that leptin may have an autocrine/paracrine role in human implantation and placentation and could be a modulator for invasive features of cytotrophoblast cells. Expand
Premature luteinization during gonadotropin-releasing hormone antagonist cycles and its relationship with in vitro fertilization outcome.
TLDR
Premature luteinization during GnRH antagonist IVF-ET cycles is a frequent event that is associated with lower pregnancy and implantation rates and may reflect the mature granulosa cell response to high FSH exposure. Expand
Clinical evidence for a detrimental effect on uterine receptivity of high serum oestradiol concentrations in high and normal responder patients.
TLDR
The clinical results demonstrate that high serum oestradiol concentrations on the day of HCG injection in high and normal responder patients, regardless of the number of oocytes retrieved and the serum progesterone concentration, are detrimental to uterine receptivity without affecting embryo quality. Expand
Evidence that the endometrial microbiota has an effect on implantation success or failure.
TLDR
The results demonstrate the existence of an endometrial microbiota that is highly stable during the acquisition of endometrian receptivity, however, pathological modification of its profile is associated with poor reproductive outcomes for in vitro fertilization patients. Expand
Genome-wide parent-of-origin DNA methylation analysis reveals the intricacies of human imprinting and suggests a germline methylation-independent mechanism of establishment.
TLDR
Pl placental-specific imprinting provides evidence for an inheritable epigenetic state that is independent of DNA methylation and the existence of a novel imprinting mechanism at these loci. Expand
Leptin and leptin receptor are expressed in the human endometrium and endometrial leptin secretion is regulated by the human blastocyst.
TLDR
The expression of leptin and its functional receptor in the endometrium and regulation of endometrial leptin secretion by the human embryo suggests that the leptin system may be implicated in the human implantation process. Expand
Targeting the vascular endothelial growth factor system to prevent ovarian hyperstimulation syndrome.
TLDR
It is suggested that the syndrome can be prevented by inducing ovulation with LH or GnRH analogues, which prevent VEGF overexpression and co-administration of a dopamine agonist inhibits phosphorylation of the receptor VEGFR-2. Expand
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