• Publications
  • Influence
Comparison of warfarin and aspirin for symptomatic intracranial arterial stenosis.
TLDR
Warfarin was associated with significantly higher rates of adverse events and provided no benefit over aspirin in this trial, and aspirin should be used in preference to warfarin for patients with intracranial arterial stenosis. Expand
Evidence-based guidelines for cardiovascular disease prevention in women.
TLDR
Expert Panel/Writing Group* Lori Mosca, MD, PhD (Chair); Lawrence J. Smith, Jr, MD; George Sopko,MD, MPH; Anne L. Taylor,MD; Brian W. Walsh, MD ; Nanette K. Wenger, MD. Expand
Evidence-Based Guidelines for Cardiovascular Disease Prevention in Women
TLDR
In the wake of the reports of the Women’s Health Initiative and the Heart and Estrogen/Progestin Replacement Study, which unexpectedly showed that combination hormone therapy was associated with adverse CVD effects, there is a heightened need to critically review and document strategies to prevent CVD in women. Expand
Use of tissue-type plasminogen activator for acute ischemic stroke: the Cleveland area experience.
TLDR
A small proportion of patients admitted with acute ischemic stroke in Cleveland received tPA; they experienced a high rate of ICH and in-hospital mortality was significantly higher among patients treated with tPA, and with mortality predicted by a model. Expand
The Warfarin-Aspirin Symptomatic Intracranial Disease Study
TLDR
A favorable risk/benefit ratio for warfarin compared with aspirin is suggested for the prevention of major vascular events in patients with symptomatic intracranial large-artery stenosis, and a prospective, randomized study is needed to confirm these findings. Expand
Evidence-Based Guidelines for Cardiovascular Disease Prevention in Women
TLDR
In the wake of the reports of the Women’s Health Initiative and the Heart and Estrogen/Progestin Replacement Study (HERS), which unexpectedly showed that combination hormone therapy was associated with adverse CVD effects, there is a heightened need to critically review and document strategies to prevent CVD in women. Expand
Predictors of Ischemic Stroke in the Territory of a Symptomatic Intracranial Arterial Stenosis
TLDR
Among patients with symptomatic intracranial stenosis, the risk of subsequent stroke in the territory of the stenotic artery is greatest with stenosis ≥70%, after recent symptoms, and in women. Expand
Cerebral hemorrhage after intra-arterial thrombolysis for ischemic stroke
TLDR
Symptomatic ICH after IA thrombolysis with r-proUK for acute ischemic stroke occurs early after treatment and has high mortality, and the risk of symptomatic I CH may be increased in patients with a blood glucose >200 mg/dL at stroke onset. Expand
West Nile virus infection
TLDR
An overlapping spectrum of meningitis, encephalitis, and myeloradiculitis occurs in CNS WNV infection, and fever, rash, abdominal and back pain, preceding a proximal, asymmetric flaccid weakness, with CSF pleocytosis help distinguish the motor syndrome from Guillain–Barré syndrome. Expand
Cooling for Acute Ischemic Brain Damage (COOL AID): An Open Pilot Study of Induced Hypothermia in Acute Ischemic Stroke
TLDR
Induced hypothermia appears feasible and safe in patients with acute ischemic stroke even after thrombolysis, and refinements of the cooling process, optimal target temperature, duration of therapy, and, most important, clinical efficacy, require further study. Expand
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