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Abnormal lung development and cleft palate in mice lacking TGF–β3 indicates defects of epithelial–mesenchymal interaction
TLDR
This study demonstrates an essential function for TGF–β3 in the normal morphogenesis of palate and lung, and directly implicates this cytokine in mechanisms of epithelial–mesenchymal interaction.
Conditional inactivation of Tgfbr2 in cranial neural crest causes cleft palate and calvaria defects
TLDR
It is demonstrated that mice with Tgfbr2 conditional gene ablation in the CNC have complete cleft secondary palate, calvaria agenesis, and other skull defects with complete phenotype penetrance and provides a model for the study of abnormal CNC development.
Multicentric peripheral ossifying fibroma.
TLDR
This case is the first one to demonstrate that there may be a multicentric variant of POF that has not been previously recognized, and given the clinical presentation and multifocal nature of disease, the lesions in this patient are likely the result of genetic mutation(s) that predisposes to gingival soft tissue overgrowths containing mineralized product.
Medial edge epithelium fate traced by cell lineage analysis during epithelial-mesenchymal transformation in vivo.
TLDR
The transition of the DiI-labeled cells from an epithelial phenotype to a mesenchymal phenotype is consistent with a fate of epithelial-mesenchyme transformation rather than programmed cell death.
Identification of microbial biofilms in osteonecrosis of the jaws secondary to bisphosphonate therapy.
TLDR
The observation of multispecies microbial biofilms on affected bone in patients with osteonecrosis of the jaws (ONJ) secondary to bisphosphonate therapy may suggest a role for microbial biofilmms in the disease process of ONJ.
Oral bisphosphonate use and the prevalence of osteonecrosis of the jaw: an institutional inquiry.
TLDR
The findings from this study indicated that even short-term oral use of alendronate led to ONJ in a subset of patients after certain dental procedures were performed, which has important therapeutic and preventive implications.
Caiman periodontium as an intermediate between basal vertebrate ankylosis‐type attachment and mammalian “true” periodontium
TLDR
Data is interpreted to indicate distinct differences in mineral distribution, periodontal ligament fiber organization, and HERS distribution between noncrocodilian reptiles, crocodilian Reptile periodontium, and mammals.
TGF‐β3–dependent SMAD2 phosphorylation and inhibition of MEE proliferation during palatal fusion
  • X. Cui, Y. Chai, +4 authors C. Shuler
  • Biology, Medicine
    Developmental dynamics : an official publication…
  • 1 July 2003
TLDR
Evidence is provided that inhibition of MEE proliferation in vivo was controlled by endogenous TGF‐β3, which may be mediated by TGF–β3–dependent phosphorylation of SMAD2.
Transforming growth factor‐β3 regulates transdifferentiation of medial edge epithelium during palatal fusion and associated degradation of the basement membrane
TLDR
A specific role for TGF‐β3 is defined in the events that control transdifferentiation of the medial edge epithelial cells including degradation of the underlying basement membrane.
Overexpression of Smad2 in Tgf-beta3-null mutant mice rescues cleft palate.
TLDR
The rescued palatal fusion in Tgf-beta3-/-/K14-Smad2 mice, however, never proceeded to the junction of primary and secondary palates and the most posterior border of the soft palate, despite phospho-SMAD2 expression in these regions at the same level as in the middle portion of the secondary palate.
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