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Radiosensitizing effect of 2,4-dinitroimidazole-1-ethanol and its cytotoxicity in HeLa S3 cells.
The radiosensitizing effect of the newly synthesized derivatives of dinitroimidazole-1-ethanol was about 10 times greater than that of misonidazoles under hypoxic conditions and its cytotoxicity was twice that ofmisonidrazole under hyp Toxic conditions and there was no apparent differential cytotoxic to hypoxic and aerobic cells. Expand
Effect of hypoxia on the cytotoxicity of misonidazole in HELA S3 cells in vitro.
Under hypoxic conditions, 5-hr exposure to 50mM misonidazole resulted in severe cytotoxicity, though the toxicity at 1mM was low, and a dose-modifying factor of 1.9 was achieved for cells irradiated with gamma rays. Expand
An approach to the design and synthesis of mercaptoimidazole derivatives containing oxidized sulfur based on electron affinity sensitization.
No appreciable activity was observed with these compounds upon in vitro screening, probably due to their low water-solubility, but this approach may be useful for the development of improved radiosensitizers provided that mercaptoimidazole derivatives with adequate water- solubility can be obtained. Expand
Effect of prolonged exposure of HELA S3 cells to low concentrations of misonidazole.
It is suggested that continuous administration of low doses of misonidazole may be efficacious as a specific chemotherapeutic in the treatment of hypoxic cells in tumor tissue. Expand
[In vivo distributions of 111In and/or 3H labeled lymphocyte in C3H/He mouse (author's transl)].
This 111In-oxine labeling method can be used as a useful tool of radionuclide imaging in kinetic studies of lymphocyte in vivo. Expand