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Cardiac progenitor-derived exosomes protect ischemic myocardium from acute ischemia/reperfusion injury.
  • L. Chen, Y. Wang, +7 authors Y. Tang
  • Chemistry, Medicine
  • Biochemical and biophysical research…
  • 15 February 2013
BACKGROUND Cardiac progenitors (CPC) mediate cardioprotection via paracrine effects. To date, most of studies focused on secreted paracrine proteins. Here we investigated the CPC-derived-exosomes onExpand
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Clinical Implication of Coronary Tortuosity in Patients with Coronary Artery Disease
Background Coronary tortuosity (CT) is a common coronary angiography finding. The exact pathogenesis, clinical implication and long-term prognosis of CT are not fully understood. The purpose of thisExpand
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Adenosine A1 receptor promotion of multinucleated giant cell formation by human monocytes: a mechanism for methotrexate-induced nodulosis in rheumatoid arthritis.
OBJECTIVE To determine why methotrexate (MTX) exacerbates rheumatoid nodules in some patients, despite the effective suppression of synovial inflammation. METHODS Phorbol myristate acetateExpand
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Baseline Fibrinolytic State and the Risk of Future Venous Thrombosis: A Prospective Study of Endogenous Tissue‐Type Plasminogen Activator and Plasminogen Activator Inhibitor
BackgroundAlthough isolated abnormalities of plasminogen activation and inhibition have been reported among selected patients with venous thrombosis, it is unclear whether these deficiencies ofExpand
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Advanced Glycation End Products Enhance Macrophages Polarization into M1 Phenotype through Activating RAGE/NF-κB Pathway
Atherosclerotic lesions are accelerated in patients with diabetes. M1 (classically activated in contrast to M2 alternatively activated) macrophages play key roles in the progression ofExpand
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MicroRNA 107 Partly Inhibits Endothelial Progenitor Cells Differentiation via HIF-1β
Endothelial progenitor cells (EPCs) play an important role in tissue repair after ischemic heart disease. In particular, the recovery of endothelial function is reliant on the ability and rate ofExpand
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A common variant on chromosome 9p21 affects the risk of early-onset coronary artery disease
Background Two single nucleotide polymorphisms (SNPs, rs10757278 and rs2383207) on chromosome 9p21 have been proved to be associated with myocardial infarction. We investigated whether these twoExpand
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Metformin Inhibits Advanced Glycation End Products-Induced Inflammatory Response in Murine Macrophages Partly through AMPK Activation and RAGE/NFκB Pathway Suppression
Advanced glycation end products (AGEs) are major inflammatory mediators in diabetes, affecting atherosclerosis progression via macrophages. Metformin slows diabetic atherosclerosis progressionExpand
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Functional polymorphisms of matrix metallopeptidase-9 and risk of coronary artery disease in a Chinese population
Matrix metallopeptidase-9 (MMP-9) plays a pivotal role in vascular remodeling and development of atherosclerotic lesion. The potentially functional MMP-9 polymorphisms may contribute to theExpand
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In Vivo Magnetic Resonance Imaging of Injected Endothelial Progenitor Cells after Myocardial Infarction in Rats
PurposeThe purpose of this study was to detect and follow transplanted superparamagnetic iron oxide (SPIO)-labeled endothelial progenitor cells (EPCs) by magnetic resonance imagingExpand
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