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Neuroendocrine tumors. A European view.
Of the non-carcinoid tumors, insulinomas, gastrinomas, and unknown types have the highest incidence, with other types being extremely rare, and the potentially remediable nature of the tumors is stressed, and frequently a good quality of life can be experienced even in the presence of metastatic disease. Expand
Two peptides, TsAP-1 and TsAP-2, from the venom of the Brazilian yellow scorpion, Tityus serrulatus: evaluation of their antimicrobial and anticancer activities.
TsAP-1 and TsAP-2 are novel scorpion venom peptides with broad spectrum antimicrobial and anticancer cell activities the potencies of which can be significantly enhanced by increasing their cationicity. Expand
Novel venom proteins produced by differential domain-expression strategies in beaded lizards and gila monsters (genus Heloderma).
The origin and evolution of venom proteins in helodermatid lizards were investigated by multidisciplinary techniques andBioactivity characterization of exendin and helokinestatin elucidated variable cardioactivity between isoforms within each class. Expand
The epidermal nerve fibre network: characterization of nerve fibres in human skin by confocal microscopy and assessment of racial variations
Human volar forearm epidermal nerve fibres are visualized by laser‐scanning confocal microscopy using the pan‐neuronal marker, protein gene‐product 9.5 and specific antibodies to substance P, calcitonin gene‐related peptide and nerve growth factor. Expand
Development of the nervous system in Dugesia tigrina during regeneration after fission and decapitation
Results indicate that two processes are involved in the formation of the new cerebral ganglion of Dugesia tigrina, where 5-HT-IR cells appear before NPF- IR cells, in contrast to the pharynx where NPF/IR cells differentiate before the 5- HT/5-HT cells. Expand
Inhibitory effects of nematode FMRFamide-related peptides (FaRPs) on muscle strips fromAscaris suum
It is shown that the effects of PF1 were also dependent on external Ca++ and were reduced by the Ca++-channel blocker verapamil, observations consistent with the finding that nematode NOS is Ca++/Ca++-dependent. Expand
Widespread distribution of histamine in the nervous system of a trematode flatworm
In general, most flatworms contain very little histamine (HA) and their nervous systems often lack, or contain very few, histaminergic elements. However, preliminary studies in our laboratory haveExpand
Granular gland transcriptomes in stimulated amphibian skin secretions.
The discovery is presented that polyadenylated mRNAs encoding dermal granular gland peptides are present in defensive skin secretions, stabilized by endogenous nucleic acid-binding amphipathic peptides, which has important implications in conservation of biodiversity within this threatened vertebrate taxon. Expand
Isolation, Localization, and Bioactivity of the FMRFamide‐Related Neuropeptides GYIRFamide and YIRFamide from the Marine Turbellarian Bdelloura candida
An important role is indicated for GYIRFamide and YirFamide in the control of neuromuscular function in turbellarians and the structure of the endogenous peptides was optimal for peak activity. Expand
Functional and Structural Diversification of the Anguimorpha Lizard Venom System*
The results obtained highlight the importance of utilizing evolution-based search strategies for biodiscovery and emphasize the largely untapped drug design and development potential of lizard venoms. Expand