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Intraoperative MRI guidance and extent of resection in glioma surgery: a randomised, controlled trial.
- C. Senft, A. Bink, K. Franz, H. Vatter, T. Gasser, V. Seifert
- The Lancet. Oncology
- 1 October 2011
BACKGROUND Intraoperative MRI is increasingly used in neurosurgery, although there is little evidence for its use. We aimed to assess efficacy of intraoperative MRI guidance on extent of resection in… Expand
The Pan-Bcl-2 Inhibitor (−)-Gossypol Triggers Autophagic Cell Death in Malignant Glioma
Antiapoptotic Bcl-2 family members suppress both apoptosis and autophagy and are of major importance for therapy resistance of malignant gliomas. To target these molecules, we used BH3 mimetics and… Expand
Inhibition of the JAK-2/STAT3 signaling pathway impedes the migratory and invasive potential of human glioblastoma cells
- C. Senft, M. Priester, +4 authors J. Weissenberger
- Biology, Medicine
- Journal of Neuro-Oncology
- 1 February 2011
The objective of current treatment strategies for glioblastoma (GBM) is cytoreduction. Unfortunately, the deleterious migratory and invasive behavior of glial tumors remains largely unattended. The… Expand
Navigated Transcranial Magnetic Stimulation and functional Magnetic Resonance Imaging – advanced adjuncts in preoperative planning for central region tumors
USEFULNESS OF INTRAOPERATIVE ULTRA LOW‐FIELD MAGNETIC RESONANCE IMAGING IN GLIOMA SURGERY
OBJECTIVE The aim of this study was to demonstrate the usefulness of a mobile, intraoperative 0.15-T magnetic resonance imaging (MRI) scanner in glioma surgery. METHODS We analyzed our prospectively… Expand
Intra-operative subcortical electrical stimulation: A comparison of two methods
OBJECTIVE For intra-operative subcortical electrical stimulation of the corticospinal tract, two techniques - originally described for cortical stimulation - have evolved: the 50-Hz-stimulation first… Expand
Glioblastoma therapy in the elderly and the importance of the extent of resection regardless of age.
OBJECT The objective of this study was to analyze whether age influences the outcome of patients with glioblastoma and whether elderly patients with glioblastoma can tolerate the same aggressive… Expand
Combination of Intraoperative Magnetic Resonance Imaging and Intraoperative Fluorescence to Enhance the Resection of Contrast Enhancing Gliomas.
BACKGROUND Evidence suggests that extent of resection (EOR) is a prognostic factor for patients harboring gliomas. Recent studies have displayed the importance of intraoperative magnetic resonance… Expand
Low field intraoperative MRI-guided surgery of gliomas: A single center experience
- C. Senft, K. Franz, C. Ulrich, A. Bink, V. Seifert
- Clinical Neurology and Neurosurgery
- 1 April 2010
INTRODUCTION The aim of this article is to report on our experience in using a low field intraoperative MRI (iMRI) system in glioma surgery and to summarize the hitherto use and benefits of iMRI in… Expand
A randomised, open label phase III trial with nimotuzumab, an anti-epidermal growth factor receptor monoclonal antibody in the treatment of newly diagnosed adult glioblastoma.
PURPOSE A randomised, open label phase III trial was conducted to evaluate efficacy of nimotuzumab, a monoclonal antibody against epidermal growth factor receptor (EGF-R) added to standard therapy… Expand