• Publications
  • Influence
Antioxidant and redox regulation of gene transcription
  • C. Sen, L. Packer
  • Biology, Medicine
  • FASEB journal : official publication of the…
  • 1 May 1996
Reactive oxygen species (ROS) are implicated in the pathogenesis of a wide variety of human diseases. Recent evidence suggests that at moderately high concentrations, certain forms of ROS such asExpand
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Human skin wounds: A major and snowballing threat to public health and the economy
In the United States, chronic wounds affect 6.5 million patients. An estimated excess of US$25 billion is spent annually on treatment of chronic wounds and the burden is rapidly growing due toExpand
  • 1,727
  • 62
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Oxidants and antioxidants in exercise.
  • C. Sen
  • Chemistry, Medicine
  • Journal of applied physiology
  • 1 September 1995
There is consistent evidence from human and animal studies that strenuous physical exercise may induce a state wherein the antioxidant defenses of several tissues are overwhelmed by excess reactiveExpand
  • 640
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MicroRNA expression in response to murine myocardial infarction: miR-21 regulates fibroblast metalloprotease-2 via phosphatase and tensin homologue.
AIMS MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression at the post-transcriptional level by either degradation or translational repression of a target mRNA. Encoded in theExpand
  • 537
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Exercise training modulates heat shock protein response in diabetic rats.
Strenuous exercise induces oxidative stress and modification of intracellular proteins. Exercise training, however, upregulates endogenous antioxidant defenses and heat shock protein (HSP)Expand
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Thiol homeostasis and supplements in physical exercise.
  • C. Sen, L. Packer
  • Chemistry, Medicine
  • The American journal of clinical nutrition
  • 1 August 2000
Thiols are a class of organic sulfur derivatives (mercaptans) characterized by the presence of sulfhydryl residues. In biological systems, thiols have numerous functions, including a central role inExpand
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Macrophage Dysfunction Impairs Resolution of Inflammation in the Wounds of Diabetic Mice
Background Chronic inflammation is a characteristic feature of diabetic cutaneous wounds. We sought to delineate novel mechanisms involved in the impairment of resolution of inflammation in diabeticExpand
  • 368
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Wound healing essentials: Let there be oxygen
  • C. Sen
  • Medicine
  • Wound repair and regeneration : official…
  • 2009
The state of wound oxygenation is a key determinant of healing outcomes. From a diagnostic standpoint, measurements of wound oxygenation are commonly used to guide treatment planning such asExpand
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Skeletal muscle and liver glutathione homeostasis in response to training, exercise, and immobilization.
Female beagle dogs were treadmill trained 40 km/day at 5.5-6.8 km/h, 15% upgrade, 5 days/wk for 55 wk. With training, hepatic and red gastrocnemius (RG) total glutathione increased, glutathioneExpand
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Molecular mechanisms of cardioprotection by a novel grape seed proanthocyanidin extract.
Free radicals and oxidative stress play a crucial role in the pathophysiology of a broad spectrum of cardiovascular diseases including congestive heart failure, valvular heart disease,Expand
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