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The vigorous immune microenvironment of microsatellite instable colon cancer is balanced by multiple counter-inhibitory checkpoints.
UNLABELLED We examined the immune microenvironment of primary colorectal cancer using immunohistochemistry, laser capture microdissection/qRT-PCR, flow cytometry, and functional analysis ofExpand
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The emerging clinical importance of non-O157 Shiga toxin-producing Escherichia coli.
In 1982, hemorrhagic colitis and hemolytic-uremic syndrome were linked to infection with Escherichia coli O157:H7, a serotype now classified as Shiga toxin-producing E. coli (STEC). Thereafter,Expand
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A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses
The intestinal flora may promote colon tumor formation. Here we explore immunologic mechanisms of colonic carcinogenesis by a human colonic bacterium, enterotoxigenic Bacteroides fragilis (ETBF).Expand
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Microbiota organization is a distinct feature of proximal colorectal cancers
Significance We demonstrate, to our knowledge for the first time, that bacterial biofilms are associated with colorectal cancers, one of the leading malignancies in the United States and abroad.Expand
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Enteric bacterial toxins: mechanisms of action and linkage to intestinal secretion.
s of the 86th Annual Meeting of the American Society for Microbiology 1986. American Society for Microbiology, Washington, D.C. 496. Shapiro, M., J. Matthews, G. Hecht, C. Delp, and J. L. Madara.Expand
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Oxidative damage targets complexes containing DNA methyltransferases, SIRT1, and polycomb members to promoter CpG Islands.
Cancer cells simultaneously harbor global losses and gains in DNA methylation. We demonstrate that inducing cellular oxidative stress by hydrogen peroxide treatment recruits DNA methyltransferase 1Expand
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Bacteroides fragilis enterotoxin cleaves the zonula adherens protein, E-cadherin.
Strains of Bacteroides fragilis associated with diarrheal disease (enterotoxigenic B. fragilis) produce a 20-kDa zinc-dependent metalloprotease toxin (B. fragilis enterotoxin; BFT) that reversiblyExpand
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The Bacteroides fragilis toxin gene is prevalent in the colon mucosa of colorectal cancer patients.
BACKGROUND Enterotoxigenic Bacteroides fragilis (ETBF) produces the Bacteroides fragilis toxin, which has been associated with acute diarrheal disease, inflammatory bowel disease, and colorectalExpand
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Microbes, microbiota, and colon cancer.
Colorectal cancer (CRC) presents a considerable disease burden worldwide. The human colon is also an anatomical location with the largest number of microbes. It is natural, therefore, to anticipate aExpand
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Enterotoxigenic Bacteroides fragilis: a Rogue among Symbiotes
  • C. Sears
  • Biology, Medicine
  • Clinical Microbiology Reviews
  • 1 April 2009
SUMMARY Enterotoxigenic Bacteroides fragilis (ETBF) strains are strains of B. fragilis that secrete a 20-kDa heat-labile zinc-dependent metalloprotease toxin termed the B. fragilis toxin (BFT). BFTExpand
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