C. Screttas

Publications147
h-index18
Citations1,303
Highly Influential Citations5
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Engineered chimeric enzymes as tools for drug discovery: generating reliable bacterial screens for the detection, discovery, and assessment of estrogen receptor modulators.
TLDR
Strong evidence is presented here that the ability of the sensor to detect ligand binding and recognize pharmacologically critical properties arises from allosteric communication between the artificially combined protein domains, where different ligand-induced conformational changes in the receptor are transmitted to the catalytic domain and translated to distinct levels of enzyme efficiency.
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New hydroxystilbenoid derivatives endowed with neuroprotective activity and devoid of interference with estrogen and aryl hydrocarbon receptor-mediated transcription.
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Perspectives in organometallic chemistry
Group 15 element imido and phosphido cages Coordination chemistry and synthetic applications Neutral clusters EnRn of the monovalent elements gallium and indium. Recent results in synthesis and…
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New drug delivery nanosystem combining liposomal and dendrimeric technology (liposomal locked-in dendrimers) for cancer therapy.
TLDR
Physicochemical methods revealed a strong, generation dependent, interaction between liposomes and dendrimers that probably is the basis for the higher loading and slower drug release from the LLDs comparing to pure liposome.
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Markownikoff two-step hydrolithiation of .alpha.-olefins. Transformation of secondary and tertiary alkyl phenyl sulfides to the relevant alkyllithium reagents
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Preparation of alkyl phenyl sulfides by electrophilically catalyzed displacement of certain nucleophiles by thiophenoxy group
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Metal alkoxide modified organometallic reagents. Preparation and stability of organolithium reagents in tetrahydrofuran in the presence of magnesium 2-ethoxyethoxide
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The diphenylmagnesium/alkali metal alkoxide system. Hydrocarbon-soluble organoalkali metal reagents
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Hydrolithiation of .alpha.-olefins by a regiospecific two-step process. Transformation of alkyl phenyl sulfides to alkyllithium reagents
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Group 15 element imido and phosphido cages: Coordination chemistry and synthetic applications
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