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Systemic immune challenges trigger and drive Alzheimer-like neuropathology in mice
BackgroundAlzheimer’s disease (AD) is the most prevalent form of age-related dementia, and its effect on society increases exponentially as the population ages. Accumulating evidence suggests thatExpand
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Regulation of GABAergic synapse formation and plasticity by GSK3β-dependent phosphorylation of gephyrin
Postsynaptic scaffolding proteins ensure efficient neurotransmission by anchoring receptors and signaling molecules in synapse-specific subcellular domains. In turn, posttranslational modificationsExpand
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Antigen presentation and tumor cytotoxicity by interferon‐γ‐treated microglial cells
In this study microglial cells isolated from brain cell cultures of newborn mice were characterized and investigated for morphology, their responses to growth factors and their functional properties.Expand
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Antigen presentation and tumor cytotoxicity by interferon-gamma-treated microglial cells.
In this study microglial cells isolated from brain cell cultures of newborn mice were characterized and investigated for morphology, their responses to growth factors and their functional properties.Expand
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Enhancement of the NMDA receptor function by reduction of glycine transporter-1 expression
The occupation of the glycine binding-site is a prerequisite for NMDA receptor activation by glutamate. To analyze the regulation of NMDA receptor function by the glycine transporter 1 (GlyT1), weExpand
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Disruption of Glycine Transporter 1 Restricted to Forebrain Neurons Is Associated with a Procognitive and Antipsychotic Phenotypic Profile
The NMDA receptor is thought to play a central role in some forms of neuronal plasticity, including the induction of long-term potentiation. NMDA receptor hypofunction can result in mnemonicExpand
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Shift of adenosine kinase expression from neurons to astrocytes during postnatal development suggests dual functionality of the enzyme
Adenosine is a potent modulator of excitatory neurotransmission, especially in seizure-prone regions such as the hippocampal formation. In adult brain ambient levels of adenosine are controlled byExpand
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Astrocyte-derived interleukin 3 as a growth factor for microglia cells and peritoneal macrophages.
Astrocytes have been shown to release an interleukin 3 (IL 3)-like factor that induces the expression of 20-alpha-hydroxysteroid-dehydrogenase (20-alpha SDH) in nu/nu spleen cells, and theExpand
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Production of macrophage colony-stimulating factor by astrocytes and brain macrophages
Morphological hallmarks of inflammatory and degenerative diseases of the brain are hypertrophy of astrocytes and accumulation of macrophages recruited from circulating blood monocytes and/or fromExpand
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Interplay between Alpha/Beta and Gamma Interferons with B, T, and Natural Killer Cells in the Defense against Herpes Simplex Virus Type 1
ABSTRACT The essential components of the immune system that control primary and chronic infection with herpes simplex virus type 1 (HSV-1) in mice were investigated. Infection within the first fewExpand
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