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Cytokine responses correlate differentially with age in infancy and early childhood
TLDR
These findings are valuable for further assessment of normal variations and maturation processes in immune cell responses and for the clinical–therapeutic monitoring of immunological status in various childhood diseases.
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Dose‐dependent Immunomodulatory Effects of Acetylsalicylic Acid and Indomethacin in Human Whole Blood: Potential Role of Cyclooxygenase‐2 Inhibition
TLDR
The data emphasize that the immunomodulating effects of NSAIDs in whole blood are dose‐dependent, and the induction of pro‐inflammatory cytokine expression by NSAIDs is potentially mediated by COX‐2 inhibition.
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Characterisation of the host inflammatory response to Staphylococcus epidermidis in neonatal whole blood
TLDR
In vitro in vitro data suggest that proinflammatory responses to S epidermidis are dependent on gestational age in preterm infants, whereas the counteracting anti-inflammatory response to Sepidmidis may not be directly related to gestationalAge.
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Does erythropoietin protect the preterm brain?
TLDR
The hypothesis is put forward that systemic administration of recombinant human erythropoietin positively affects the neurodevelopmental outcome of high risk preterm infants affected by brain injury and a multicentre, randomised, placebo controlled study is proposed to prospectively test this hypothesis.
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Immunosuppressive Activity of the Immunophilin‐binding Drug Sanglifehrin A in Human Whole Blood: Potent Inhibition of Interleukin‐6 Produced by Lymphocytes and Monocytes
TLDR
Investigation of the impact of SFA on monocyte responses and T‐lymphocyte activity/proliferation upon lipopolysaccharide stimulation and anti‐CD3/anti‐CD28 costimulation found novel aspects of the unique immunosuppressive action could strongly impact on future clinical application.
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Renal complications associated with human parvovirus B19 infection in early childhood.
TLDR
This case report underlines renal complications of parvovirus B19 infection in early childhood including haemolytic-uraemic syndrome (HUS)-like episodes, and potential pathogenetic mechanisms are discussed.
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Failure to thrive in a 14-month-old boy with lymphopenia and eosinophilia.
TLDR
The case of a 14-month-old boy with delayed-onset SCID due to ADA-deficiency which was masqueraded only by failure to thrive is described, which shows no serious infections and an adequate immune response.
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Clinical phenotype and functional analysis of a rare XIAP/BIRC4 mutation.
TLDR
The case of a 5-year-old boy with a novel mutation of the XIAP/BIRC4 gene is presented and a distinct immunological phenotype is characterized for the first time, and the family history is evaluated accordingly.
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Topical Clotrimazole/Betamethasone use in Oral Erosive Lichen Planus
TLDR
Oral lichen planus is not a curable condition, and as such, treatment is mostly palliative and focused on alleviating symptoms and minimizing scarring, which includes both non-pharmacologic and pharmacologic therapy.
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Tuberous Sclerosis Complex as a cause of prenatally diagnosed polycystic kidney disease
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