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Type III restriction endonucleases translocate DNA in a reaction driven by recognition site‐specific ATP hydrolysis.
Type III restriction/modification systems recognize short non‐palindromic sequences, only one strand of which can be methylated. Replication of type III‐modified DNA produces completely unmethylatedExpand
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AChBP-targeted α-conotoxin correlates distinct binding orientations with nAChR subtype selectivity
Neuronal nAChRs are a diverse family of pentameric ion channels with wide distribution throughout cells of the nervous and immune systems. However, the role of specific subtypes in normal andExpand
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NOSIP, a novel modulator of endothelial nitric oxide synthase activity
Production of nitric oxide (NO) in endothelial cells is regulated by direct interactions of endothelial nitric oxide synthase (eNOS) with effector proteins such as Ca2+‐calmodulin, byExpand
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Cooperative Binding Properties of Restriction Endonuclease EcoRII with DNA Recognition Sites*
EcoRII is a member of the expanding group of type IIe restriction endonucleases that share the distinguishing feature of requiring cooperativity between two recognition sites in their substrate DNA.Expand
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The significance of distance and orientation of restriction endonuclease recognition sites in viral DNA genomes.
Studies on phage T3 and T7 have shown that these viruses avoid restriction not only by the phage-coded Ocr (and S-adenosylmethionine hydrolase) protein functions or by the complete loss of specificExpand
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Palmitoyl:protein thioesterase (PPT1) inhibitors can act as pharmacological chaperones in infantile Batten disease.
Competitive inhibitors of lysosomal hydrolases (pharmacological chaperones) have been used to treat some lysosomal storage diseases which result from mis-sense mutations and mis-folded protein butExpand
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Regions of Endonuclease EcoRII Involved in DNA Target Recognition Identified by Membrane-bound Peptide Repertoires*
Target sequence-specific DNA binding regions of the restriction endonuclease EcoRII were identified by screening a membrane-bound EcoRII-derived peptide scan with an EcoRII recognition site (CCWGG)Expand
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Unusual occurrence of EcoP1 and EcoP15 recognition sites and counterselection of type II methylation and restriction sequences in bacteriophage T7 DNA.
Selected and counterselected oligodeoxynucleotide sequences were identified in the total sequence of bacteriophage T7 DNA using a statistical criterion derived for a probability model of the MarkovExpand
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Mutual activation of two restriction endonucleases: interaction of EcoP1 and EcoP15.
Type III restriction endonucleases recognize nonsymmetric nucleotide sequences. A necessary condition for DNA cleavage is the presence of two unmethylated recognition sites which are inverselyExpand
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DNA polymerase of phage T4 antimutator mutant CB121
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