Share This Author
The Genome of the Ctenophore Mnemiopsis leidyi and Its Implications for Cell Type Evolution
The genome of the ctenophore the warty comb jelly or sea walnut, Mnemiopsis leidyi, is sequenced and it is concluded that c tenophores alone, not sponges or the clade consisting of both ctenphores and cnidarians, are the most basal extant animals.
BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein.
- M. Farzan, C. Schnitzler, N. Vasilieva, D. Leung, H. Choe
- BiologyProceedings of the National Academy of Sciences…
It is shown that BACE2 contributes to Abeta production in individuals bearing the Flemish mutation, and that selective inhibition of these highly similar proteases may be feasible and therapeutically advantageous.
BACE2, a β-secretase homolog, cleaves at the β site and within the amyloid-β region of the amyloid-β precursor protein
It is shown that BACE2 contributes to Aβ production in individuals bearing the Flemish mutation, and that selective inhibition of these highly similar proteases may be feasible and therapeutically advantageous.
Stem cell differentiation trajectories in Hydra resolved at single-cell resolution
A molecular map of Hydra cell states is provided, including differentiation trajectories for each lineage, identification of candidate regulators of cell states, and a spatial/molecular map of the nervous system.
Apoptosis and autophagy as mechanisms of dinoflagellate symbiont release during cnidarian bleaching: every which way you lose
- S. Dunn, C. Schnitzler, V. Weis
- BiologyProceedings of the Royal Society B: Biological…
- 22 December 2007
This study investigated the roles of two cellular pathways, host cell apoptosis and autophagy, in the bleaching process of the symbiotic anemone Aiptasia pallida and indicated that no single pathway is responsible for symbiont release during bleaching.
Whole genome comparison of a large collection of mycobacteriophages reveals a continuum of phage genetic diversity
To understand the population structure of phages infecting a single host strain, 627 phages of Mycobacterium smegmatis were isolated, sequenced, and compared to reveal a continuum of genetic diversity, albeit with uneven representation of different phages.
Regulation of cnidarian-dinoflagellate mutualisms: Evidence that activation of a host TGFβ innate immune pathway promotes tolerance of the symbiont.
MicroRNAs and essential components of the microRNA processing machinery are not encoded in the genome of the ctenophore Mnemiopsis leidyi
- Evan K. Maxwell, J. Ryan, C. Schnitzler, W. E. Browne, A. Baxevanis
- BiologyBMC Genomics
- 20 December 2012
This study uses short RNA sequencing and the assembled genome of the lobate ctenophore Mnemiopsis leidyi to show that this species appears to lack any recognizable microRNAs, as well as the nuclear proteins Drosha and Pasha, which are critical to canonical microRNA biogenesis.
A Tyrosine-sulfated Peptide Based on the N Terminus of CCR5 Interacts with a CD4-enhanced Epitope of the HIV-1 gp120 Envelope Glycoprotein and Inhibits HIV-1 Entry*
It is demonstrated that a tyrosine-sulfated peptide based on the N terminus of CCR5, but not its unsulfated analogue, inhibits infection of macrophages and peripheral blood mononuclear cells by C CR5-dependent, butNot CXCR4- dependent, HIV-1 isolates.
Tyrosine-sulfated Peptides Functionally Reconstitute a CCR5 Variant Lacking a Critical Amino-terminal Region*
It is shown that a tyrosine-sulfated region of the CCR5 amino terminus can function independently to mediate association of chemokines and the HIV-1 envelope glycoprotein with the remaining domains of C CR5.