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ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology
Free ADP-ribose (ADPR), a product of NAD hydrolysis and a breakdown product of the calcium-release second messenger cyclic ADPR (cADPR), has no defined role as an intracellular signalling molecule inExpand
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Regulation of Vertebrate Cellular Mg2+ Homeostasis by TRPM7
TRPM7 is a polypeptide with intrinsic ion channel and protein kinase domains whose targeted deletion causes cells to experience growth arrest within 24 hr and eventually die. Here, we show that whileExpand
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Accumulation of Free ADP-ribose from Mitochondria Mediates Oxidative Stress-induced Gating of TRPM2 Cation Channels*
TRPM2 is a member of the transient receptor potential melastatin-related (TRPM) family of cation channels, which possesses both ion channel and ADP-ribose hydrolase functions. TRPM2 has been shown toExpand
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The Channel Kinases TRPM6 and TRPM7 Are Functionally Nonredundant*
TRPM7 and its closest homologue, TRPM6, are the only known fusions of an ion channel pore with a kinase domain. Deletion of TRPM7 in DT40 B-lymphocytes causes growth arrest, Mg2+ deficiency, and cellExpand
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Altered functional properties of a TRPM2 variant in Guamanian ALS and PD
Two related neurodegenerative disorders, Western Pacific amyotrophic lateral sclerosis (ALS) and parkinsonism–dementia (PD), originally occurred at a high incidence on Guam, in the Kii peninsula ofExpand
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TRPM2 Ca2+ permeable cation channels: from gene to biological function.
TRPM2 is a recently identified TRPM family cation channel which is unique among known ion channels in that it contains a C-terminal domain which is homologous to the NUDT9 ADP-ribose hydrolase andExpand
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The TRPM6 Kinase Domain Determines the Mg·ATP Sensitivity of TRPM7/M6 Heteromeric Ion Channels*
Background: TRPM6 and TRPM7 combine ion channel and α-kinase functions. Results: ATP inhibits TRPM7 but not TRPM6 or heteromeric TRPM6/M7 channels. Disruption of phosphorylation activity of TRPM6Expand
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Receptor-mediated regulation of the TRPM7 channel through its endogenous protein kinase domain.
TRPM7 is a ubiquitously expressed and constitutively active divalent cation-selective ion channel, whose basal activity is regulated by intracellular levels of Mg(2+) and Mg.ATP. We have investigatedExpand
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The channel-kinase TRPM7 regulates phosphorylation of the translational factor eEF2 via eEF2-k.
Protein translation is an essential but energetically expensive process, which is carefully regulated in accordance to the cellular nutritional and energy status. Eukaryotic elongation factor 2Expand
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Once-Daily Oral Sarecycline 1.5 mg/kg/day Is Effective for Moderate to Severe Acne Vulgaris: Results from Two Identically Designed, Phase 3, Randomized, Double-Blind Clinical Trials.
BACKGROUND Side effects may limit the use of current tetracycline-class antibiotics for acne. OBJECTIVE Evaluate the efficacy and safety of once-daily sarecycline, a novel, narrow-spectrumExpand
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