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Structure and action of the binary C2 toxin from Clostridium botulinum.
- C. Schleberger, Henrike Hochmann, Holger Barth, K. Aktories, G. Schulz
- Medicine, Chemistry
- Journal of molecular biology
- 8 December 2006
C2 toxin from Clostridium botulinum is composed of the enzyme component C2-I, which ADP-ribosylates actin, and the binding and translocation component C2-II, responsible for the interaction with… Expand
High-resolution crystal structure of the snake venom metalloproteinase BaP1 complexed with a peptidomimetic: insight into inhibitor binding.
BaP1, a zinc-dependent endopeptidase belonging to the P-I class of snake venom metalloproteinases, exerts multiple tissue-damaging activities, leading to hemorrhage, myonecrosis, dermonecrosis,… Expand
Binding structure of elastase inhibitor scyptolin A.
- U. Matern, C. Schleberger, S. Jelakovic, J. Weckesser, G. Schulz
- Chemistry, Medicine
- Chemistry & biology
- 1 October 2003
Natural bioactive compounds are of general interest to pharmaceutical research because they may be used as leads in drug development campaigns. Among them, scyptolin A and B from Scytonema hofmanni… Expand
Engineering a function into a glycosyltransferase.
- Christine Krauth, M. Fedoryshyn, C. Schleberger, A. Luzhetskyy, A. Bechthold
- Medicine, Biology
- Chemistry & biology
- 30 January 2009
As glycosyltransferases found in nature often show distinct substrate specificity, glycosyltransferase engineering is an important research field. In this work, we were able to introduce an activity… Expand
Structure and Action of a CC Bond Cleaving α/β-Hydrolase Involved in Nicotine Degration
Abstract The enzyme 2,6-dihydroxy-pseudo-oxynicotine hydrolase from the nicotine-degradation pathway of Arthrobacter nicotinovorans was crystallized and the structure was determined by an X-ray… Expand
Binding structure of the leucine aminopeptidase inhibitor microginin FR1
Natural bioactive compounds are of general interest for pharmaceutical research because they may serve as leads in drug development campaigns. Among them, microginins are linear peptides known to… Expand
High-resolution crystal structure of the P-I snake venom metalloproteinase BaP1 in complex with a peptidomimetic: insights into inhibitor binding
Structure and action of a C-C bond cleaving alpha/beta-hydrolase involved in nicotine degradation.
The enzyme 2,6-dihydroxy-pseudo-oxynicotine hydrolase from the nicotine-degradation pathway of Arthrobacter nicotinovorans was crystallized and the structure was determined by an X-ray diffraction… Expand
Crystal Structure of the 2,6-dihydroxy-pseudo-oxynicotine Hydrolase.