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Powerful Cocaine-Like Actions of 3,4-Methylenedioxypyrovalerone (MDPV), a Principal Constituent of Psychoactive ‘Bath Salts’ Products
The data show that MDPV is a monoamine transporter blocker with increased potency and selectivity for catecholamines when compared with cocaine, and may provide a mechanism to explain the adverse effects observed in humans taking high doses of ‘bath salts’ preparations.
Nicotine self-administration in rats: strain and nicotine pre-exposure effects on acquisition
The results support previous reports that nicotine can serve as a reinforcer in rodents and demonstrate that environmental factors such as prior nicotine exposure or genetic factorssuch as rat strain can affect acquisition of nicotine self-administration.
Effects of dopamine agonists and antagonists on locomotor activity in male and female rats
The GABAB agonist baclofen modifies cocaine self-administration in rats.
- M. Shoaib, L. S. Swanner, C. Beyer, S. Goldberg, C. Schindler
- Biology, PsychologyBehavioural pharmacology
- 1 May 1998
Modulation of GABA systems may have therapeutic potential for the treatment of psychomotor stimulant abuse and is demonstrated to demonstrate extinction selectively for each reinforcer.
Reinforcing and neurochemical effects of the “bath salts” constituents 3,4-methylenedioxypyrovalerone (MDPV) and 3,4-methylenedioxy-N-methylcathinone (methylone) in male rats
The hypothesis that elevations in extracellular 5-HT in the brain can dampen positive reinforcing effects of cathinone-type drugs is supported.
The reinforcing and subjective effects of morphine in post-addicts: a dose-response study.
- R. Lamb, K. Preston, S. Goldberg
- PsychologyThe Journal of pharmacology and experimental…
- 1 December 1991
The results indicate that there can be a significant dissociation of the reinforcing and the subjective effects of opioids, which has implications for theories of opioid abuse, particularly those assuming that the reinforcing effects are causally related to the euphoric effect of opioids.
Second-order schedules of drug self-administration in animals
These studies clearly showed that environmental stimuli greatly influence drug self-administration behavior under second-order schedules, and holds great promise for delineating specific brain regions critical to different aspects of drug addiction.
Self-administration of remifentanil, an ultra-short acting opioid, under continuous and progressive-ratio schedules of reinforcement in rats
Although rates of self-administration are clearly influenced by a drug's duration ofaction, the ability to maintain responding under intermittent schedules of reinforcement may be independent of duration of action.
Cocaine reward and MPTP toxicity: alteration by regional variant dopamine transporter overexpression.
Role of central and peripheral adenosine receptors in the cardiovascular responses to intraperitoneal injections of adenosine A1 and A2A subtype receptor agonists
- C. Schindler, M. Karcz-Kubicha, S. Goldberg
- Biology, MedicineBritish journal of pharmacology
- 1 March 2005
It is suggested that adenosine A1 receptor agonists produce decreases in blood pressure and heart rate that are mediated by A1 receptors in the periphery, with little or no contribution of central adenosines A1 antagonists to those effects.