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Effect of Chemokine Receptors CXCR4 and CCR7 on the Metastatic Behavior of Human Colorectal Cancer
Strong expression of CXCR4 by colorectal cancer cells is significantly associated with lymphatic and distant dissemination in patients with coloreCTal cancer as well as with cancer cell migration in vitro. Expand
Dissemination of hepatocellular carcinoma is mediated via chemokine receptor CXCR4
Exposure to CXCL12 mediated a perinuclear translocation of CXCR4 in Huh7/Hep3B cells and increased the invasive potential of Huh7 cells. Expand
Chemokine receptor CXCR4-prognostic factor for gastrointestinal tumors.
CXCR4 and its ligands influence the dissemination, immune rejection, and neoangiogenesis of human gastrointestinal cancers, and inhibition of CX CR4 might be an interesting therapeutic option. Expand
High miR-196a levels promote the oncogenic phenotype of colorectal cancer cells.
AIM To analyze the relevance of the microRNA miR-196a for colorectal oncogenesis. METHODS The impact of miR-196a on the restriction targets HoxA7, HoxB8, HoxC8 and HoxD8 was analyzed by reverseExpand
Reduced expression of Hugl-1, the human homologue of Drosophila tumour suppressor gene lgl, contributes to progression of colorectal cancer
Evaluated tumour tissues from 94 patients undergoing surgery for colorectal cancer for loss of Hugl-1 transcription and compared these findings with the clinical data from each of these patients found that HugL-1 was lost in 75% of tumours and these losses were associated with advanced stage and particularly with lymph node metastases. Expand
Capecitabine and irinotecan with and without bevacizumab for advanced colorectal cancer patients.
Both regimens were well tolerated and offered effective tumor growth control in this outpatient setting and if observed were never fatal. Expand
Strong expression of chemokine receptor CXCR4 by pancreatic cancer correlates with advanced disease.
Strong expression of CXCR4 was significantly associated with advanced pancreatic cancer and a trend for hematogenous metastasis was revealed. Expand
Phenprocoumon-induced liver disease ranges from mild acute hepatitis to (sub-) acute liver failure.
Phenprocoumon-induced liver disease is an uncommon complication, which can, however, cause (sub-) acute liver failure. Expand
VEGF-D expression correlates with colorectal cancer aggressiveness and is downregulated by cetuximab.
The expression of VEGF-D in colorectal tumours is significantly associated with lymphatic involvement in CRC patients and such expression might be blocked effectively by cetuximab. Expand
Rectal cancer: Dynamic contrast‐enhanced MRI correlates with lymph node status and epidermal growth factor receptor expression
To evaluate correlations between dynamic contrast‐enhanced magnetic resonance imaging (DCE‐MRI) and clinicopathologic data as well as immunostaining of the markers of angiogenesis epidermal growthExpand