• Publications
  • Influence
Pathophysiology of REM sleep behaviour disorder and relevance to neurodegenerative disease.
TLDR
The data suggest that many patients with 'idiopathic' RBD are actually exhibiting an early clinical manifestation of an evolving neurodegenerative disorder, and may be appropriate for future drug therapies that affect synuclein pathophysiology, in which the development of parkinsonism and/or dementia could be delayed or prevented.
Delayed emergence of a parkinsonian disorder in 38% of 29 older men initially diagnosed with idiopathic rapid eye movement sleep behavior disorder
TLDR
RBD can be the heralding manifestation of Parkinson's disease in a substantial subgroup of older male RBD patients, and the pedunculopontine nucleus is implicate as a likely site of pathology in combined RBD-Parkinson's disease, based on experimental and theoretical considerations rather than on autopsy data.
Proposed diagnostic criteria for night eating syndrome.
TLDR
Criteria for diagnosis of the night eating syndrome is an abnormally increased food intake in the evening and nighttime, manifested by consumption of at least 25% of intake after the evening meal, and/or nocturnal awakenings with ingestions at least twice per week.
Chronic behavioral disorders of human REM sleep: a new category of parasomnia.
TLDR
These REM sleep neurobehavioral disorders constitute another category of parasomnia, replicate findings from 21 years ago in cats receiving pontine tegmental lesions, and offer additional perspectives on human behavior, neurophysiology, pharmacology, and dream phenomenology.
Insights from studying human sleep disorders
TLDR
Contrary to common assumptions, wakefulness, rapid eye movement (REM) and non-REM sleep are not mutually exclusive states, and this striking realization explains a fascinating range of clinical phenomena.
A polysomnographic and clinical report on sleep-related injury in 100 adult patients.
In 100 consecutive adults who came to a sleep disorders center complaining of repeated nocturnal injury, polysomnographic study identified five disorders: night terrors/sleepwalking (N = 54), REM
Cognitive Slowing and Working Memory Difficulties in Chronic Fatigue Syndrome
TLDR
It is concluded that, although CFS and major depression and dysthymia have distinct clinical features, these disorders have slowed motor and cognitive processing speed in common.
POLYSOMNOGRAPHIC, NEUROLOGIC, PSYCHIATRIC, AND CLINICAL OUTCOME REPORT ON 70 CONSECUTIVE CASES WITH REM SLEEP BEHAVIOR DISORDER (RBD) : SUSTAINED CLON AZEPAM EFFICAY IN 89.5% OF 57 TREATED PATIENTS
TLDR
A series of RBD cases reported herein was gathered in a setting with an extensive referral base and came to the regional sleep disorders center for evaluation of frequently injurious and poten-tially life-threatening conditions requiring specialized diagnostic tests as well as a search for safe and effective treatment.
...
...