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Arteriolar niches maintain haematopoietic stem cell quiescence
TLDR
It is shown that quiescent HSCs associate specifically with small arterioles that are preferentially found in endosteal bone marrow, indicating that arteriolar niches are indispensable for maintaining HSC quiescence. Expand
Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche
TLDR
Results highlight two antagonistic, tightly balanced pathways that regulate maintenance of HSCs/progenitors in the niche during homeostasis, in which MΦ cross talk with the Nestin+ niche cell promotes retention, and in contrast, SNS signals enhance egress. Expand
Neutrophil ageing is regulated by the microbiome
TLDR
It is shown that neutrophil pro-inflammatory activity correlates positively with their ageing whilst in circulation, and a role for the microbiota in regulating a disease-promoting neutrophils subset is identified. Expand
Adrenergic nerves govern circadian leukocyte recruitment to tissues.
TLDR
It is shown that broad systemic programs involving long-range signals from the sympathetic nervous system (SNS) delivered by adrenergic nerves regulate rhythmic recruitment of leukocytes in tissues and have physiological consequences through alteration of hematopoietic cell recruitment and overall survival in models of septic shock, sickle cell vaso-occlusion, and BM transplantation. Expand
Mesenchymal stem cell: keystone of the hematopoietic stem cell niche and a stepping-stone for regenerative medicine.
TLDR
The definition of MSCs is examined and the importance of rigorously characterizing their stem cell activity is discussed, as well as potential therapeutic implications. Expand
Megakaryocytes regulate hematopoietic stem cell quiescence via Cxcl4 secretion
TLDR
It is shown that megakaryocytes (MKs) can directly regulate HSC pool size in mice, indicating that a terminally differentiated cell type derived from HSCs contributes to the HSC niche, directly regulating HSC behavior. Expand
Disruption of neurofascin localization reveals early changes preceding demyelination and remyelination in multiple sclerosis.
TLDR
The alterations in oligodendrocyte Nfasc155 expression that accompany inflammation and demyelination suggest an ongoing disruption to the axonal-oligodendROcyte complex within newly forming as well as established lesions in multiple sclerosis, resulting in destruction of the N fasc186+/Na+v nodal complex vital to successful fast neurotransmission in the CNS. Expand
Circadian control of the immune system
TLDR
The current knowledge of circadian rhythms in the immune system is summarized and an outlook on potential future implications is provided. Expand
JAM-A mediates neutrophil transmigration in a stimulus-specific manner in vivo: evidence for sequential roles for JAM-A and PECAM-1 in neutrophil transmigration.
TLDR
Investigation of the functional relationship between JAM-A and PECAM-1 determined that dual blockade/deletion of these proteins does not lead to an inhibitory effect greater than that seen with blockade/ deletions of either molecule alone. Expand
Venular basement membranes contain specific matrix protein low expression regions that act as exit points for emigrating neutrophils
TLDR
A plausible mechanism by which neutrophil penetrate the vascular BM without causing a gross disruption to its intricate structure is identified and evidence was obtained indicating that transmigrating neutrophils carry laminins on their cell surface in vivo. Expand
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