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NF-κB Function in Growth Control: Regulation of Cyclin D1 Expression and G0/G1-to-S-Phase Transition
- M. Hinz, D. Krappmann, A. Eichten, Andreas Heder, C. Scheidereit, M. Strauss
- BiologyMolecular and Cellular Biology
- 1 April 1999
NF-κB contributes to cell cycle progression, and one of its targets might be cyclin D1, a key regulator of G1checkpoint control.
Tissue-specific expression of a splicing mutation in the IKBKAP gene causes familial dysautonomia.
It is indicated that almost all cases of FD are caused by an unusual splice defect that displays tissue-specific expression; and they also provide the basis for rapid carrier screening in the Ashkenazi Jewish population.
Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta-catenin signaling pathways in hair follicle induction.
IkappaB kinase complexes: gateways to NF-kappaB activation and transcription.
- C. Scheidereit
Nuclear IKK components have been found to act directly at the chromatin level of induced genes and to mediate responses to DNA damage, and IKK is engaged in cross talk with other pathways and confers functions independently of NF-kappaB.
A nuclear poly(ADP-ribose)-dependent signalosome confers DNA damage-induced IkappaB kinase activation.
A cytoplasmic ATM-TRAF6-cIAP1 module links nuclear DNA damage signaling to ubiquitin-mediated NF-κB activation.
IκB kinase complexes: gateways to NF-κB activation and transcription
- C. Scheidereit
- 30 October 2006
Nuclear IKK components have been found to act directly at the chromatin level of induced genes and to mediate responses to DNA damage, and IKK is engaged in cross talk with other pathways and confers functions independently of NF-κB.
Aberrantly expressed c‐Jun and JunB are a hallmark of Hodgkin lymphoma cells, stimulate proliferation and synergize with NF‐κB
Activated AP‐1 supports proliferation of Hodgkin cells, while it suppresses apoptosis of ALCL cells and stimulates expression of the cell‐cycle regulator cyclin D2, proto‐oncogene c‐met and the lymphocyte homing receptor CCR7, which are all strongly expressed in primary HRS cells.
Purification and Characterization of the Human Elongator Complex*
Several human homologues of the yeast Elongator subunits were identified as subunits of the human Elongators, including StIP1 (STAT-interacting protein1) and IKAP (IKK complex-associatedprotein), raising the possibility that this disease might be due to compromised ElongATOR function and therefore could be a transcription disorder.
The glucocorticoid receptor binds to defined nucleotide sequences near the promoter of mouse mammary tumour virus
The receptor binding region is delimited to a DNA segment of 152 base pairs that has been shown to be relevant for hormonal induction and partially homologous receptor binding sequences located in this region are identified.