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Dietary factors and low-grade inflammation in relation to overweight and obesity
TLDR
Potential mechanisms are described and research gaps, which limit the understanding of the interaction between diet and postprandial and chronic low-grade inflammation, are identified.
View on Cambridge Press
Disease variants alter transcription factor levels and methylation of their binding sites
TLDR
It is shown that disease-associated variants have widespread effects on DNA methylation in trans that likely reflect differential occupancy of trans binding sites by cis-regulated transcription factors.
View on Nature
Inflammatory markers, adiponectin, and risk of type 2 diabetes in the Pima Indian.
TLDR
Adiponectin is negatively correlated with markers of inflammation in vivo and may be the link between adiposity, inflammation, and type 2 diabetes.
View on PubMed
Vascular complications in diabetes mellitus: the role of endothelial dysfunction.
TLDR
Endothelial dysfunction in diabetes originates from three main sources: Hyperglycaemia, microalbuminuria and the components of the metabolic syndrome can impair endothelial function.
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Analysis of advanced glycation endproducts in selected food items by ultra-performance liquid chromatography tandem mass spectrometry: Presentation of a dietary AGE database.
View on PubMed
Diastolic stiffness of the failing diabetic heart: importance of fibrosis, advanced glycation end products, and myocyte resting tension.
TLDR
Mechanisms responsible for the increased diastolic stiffness of the diabetic heart differ in heart failure with reduced and normal LVEF: Fibrosis and AGEs are more important when LveF is reduced, whereas cardiomyocyte resting tension is more importantWhen LVEf is normal.
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Plasma concentration of C-reactive protein is increased in Type I diabetic patients without clinical macroangiopathy and correlates with markers of endothelial dysfunction: evidence for chronic…
TLDR
Plasma concentrations of C-reactive protein were higher in Type I diabetic patients without (clinical) macroangiopathy than in control subjects, probably due to a chronic hepatic inflammatory response.
View on Springer
Long-term exposure to new peritoneal dialysis solutions: Effects on the peritoneal membrane.
TLDR
Long-term in vivo exposure to standard PDF adversely affects peritoneal function and structure and a low-GDP bicarbonate/lactate-buffered and amino acid-based PDF better preservedperitoneal integrity and may thus improve the longevity of the peritoneAL membrane.
View on PubMed
Identification of context-dependent expression quantitative trait loci in whole blood
TLDR
This work generated peripheral blood RNA–seq data from 2,116 unrelated individuals and systematically identified context-dependent eQTLs using a hypothesis-free strategy that does not require previous knowledge of the identity of the modifiers.
View on Nature
Overexpression of Glyoxalase-I Reduces Hyperglycemia-induced Levels of Advanced Glycation End Products and Oxidative Stress in Diabetic Rats*
TLDR
This study shows for the first time in an in vivo model of diabetes that GLO-I overexpression reduces hyperglycemia-induced levels of carbonyl stress, AGEs, and oxidative stress.
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