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Two-Photon Imaging of Cortical Surface Microvessels Reveals a Robust Redistribution in Blood Flow after Vascular Occlusion
A highly interconnected network of arterioles overlies mammalian cortex to route blood to the cortical mantle. Here we test if this angioarchitecture can ensure that the supply of blood isExpand
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In vivo three-photon microscopy of subcortical structures within an intact mouse brain
  • N. Horton, K. Wang, +4 authors C. Xu
  • Physics, Medicine
  • Conference on Lasers and Electro-Optics (CLEO)
  • 20 January 2013
We demonstrate non-invasive, high-resolution, in vivo imaging of subcortical structures (the external capsule (EC) and hippocampus) within an intact mouse brain using three-photon fluorescenceExpand
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Age-Related Intimal Stiffening Enhances Endothelial Permeability and Leukocyte Transmigration
Inhibiting endothelial cell contractility reverses the deleterious effects of age-related matrix stiffening on normal cell function, which could help prevent the development of atherosclerosis. RockExpand
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Penetrating arterioles are a bottleneck in the perfusion of neocortex
Penetrating arterioles bridge the mesh of communicating arterioles on the surface of cortex with the subsurface microvascular bed that feeds the underlying neural tissue. We tested the conjectureExpand
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Targeted insult to subsurface cortical blood vessels using ultrashort laser pulses: three models of stroke
We present a method to produce vascular disruptions within rat brain parenchyma that targets single microvessels. We used two-photon microscopy to image vascular architecture, to select a vessel forExpand
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Two-Photon Microscopy as a Tool to Study Blood Flow and Neurovascular Coupling in the Rodent Brain
The cerebral vascular system services the constant demand for energy during neuronal activity in the brain. Attempts to delineate the logic of neurovascular coupling have been greatly aided by theExpand
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Chronic in vivo imaging in the mouse spinal cord using an implanted chamber
Understanding and treatment of spinal cord pathology is limited in part by a lack of time-lapse in vivo imaging strategies at the cellular level. We developed a chronically implanted spinal chamberExpand
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In vivo imaging of myelin in the vertebrate central nervous system using third harmonic generation microscopy.
Loss of myelin in the central nervous system (CNS) leads to debilitating neurological deficits. High-resolution optical imaging of myelin in the CNS of animal models is limited by a lack of in vivoExpand
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Preictal and Ictal Neurovascular and Metabolic Coupling Surrounding a Seizure Focus
Epileptic events initiate a large focal increase in metabolism and cerebral blood flow (CBF) to the ictal focus. In contrast, decreases in CBF have been demonstrated surrounding the focus, theExpand
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Ablation of cytoskeletal filaments and mitochondria in live cells using a femtosecond laser nanoscissor.
Analysis of cell regulation requires methods for perturbing molecular processes within living cells with spatial discrimination on the nanometer-scale. We present a technique for ablating molecularExpand
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